191800-48-3Relevant academic research and scientific papers
4-[ω-(tetralin-1-yl)alkyl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands
Perrone, Roberto,Berardi, Francesco,Colabufo, Nicola A.,Leopoldo, Marcello,Lograno, Marcello D.,Tortorella, Vincenzo
, p. 76 - 86 (2007/10/03)
N-Benzylpiperazine and -piperidine derivatives of long-chain piperazine were synthesized in order to obtain putative atypical antipsychotic agents with a dual 5-HT1A/D-2 affinity and reduced, or without, α1 adrenergic affinity. The 5-HT1A/D-2/α1 receptor binding results show that only compound 30, 2-(2-methoxybenzyl)-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-n-propyl] piperazine, has an acceptable binding affinity profile (pKi= 7.9, 7.1, 6.7, respectively).
