191869-08-6 Usage
Uses
Used in Pharmaceutical Industry:
(4-Amino-3,5-dibromo-phenyl)-acetic acid is used as a starting material for the production of various drugs and pharmaceutical intermediates. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Organic Synthesis:
(4-Amino-3,5-dibromo-phenyl)-acetic acid is used as a building block in the synthesis of complex organic compounds. Its reactivity and functional groups allow for the formation of a wide range of chemical products.
Used in Chemical Analysis:
(4-Amino-3,5-dibromo-phenyl)-acetic acid is used as a reagent in chemical analysis, aiding in the identification and quantification of various substances.
Used in Antimicrobial Applications:
(4-Amino-3,5-dibromo-phenyl)-acetic acid is used for its antimicrobial properties, helping to combat bacterial infections and contributing to the development of new antimicrobial agents.
Used in Anti-inflammatory Applications:
(4-Amino-3,5-dibromo-phenyl)-acetic acid is used for its anti-inflammatory effects, potentially contributing to the treatment of various inflammatory conditions and diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 191869-08-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,8,6 and 9 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 191869-08:
(8*1)+(7*9)+(6*1)+(5*8)+(4*6)+(3*9)+(2*0)+(1*8)=176
176 % 10 = 6
So 191869-08-6 is a valid CAS Registry Number.
191869-08-6Relevant academic research and scientific papers
Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin
Kang, Dong Wook,Kim, Yong Soo,Lim, Kwang Su,Kim, Myeong Seop,Pearce, Larry V.,Pavlyukovets, Vladimir A.,Tao, Andy K.,Lang-Kuhs, Krystle A.,Blumberg, Peter M.,Lee, Jeewoo
experimental part, p. 8092 - 8105 (2011/01/13)
As an extension of our analysis of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3- methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1 binding and regulation and for their pattern of agonism/antagonism (efficacy). Halogenation shifted the functional activity at TRPV1 toward antagonism with a greater extent of antagonism as the size of the halogen increased (I > Br > Cl), as previously observed for the thiourea series. The extent of antagonism was greater for halogenation at the 5-position than at the 6-position, in contrast to SAR for the thiourea series. In this series, compounds 55 and 75 showed the most potent antagonism, with Ki (ant) = 2.77 and 2.19 nM, respectively, on rTRPV1 expressed in Chinese hamster ovary cells. The compounds were thus ca. 40-60-fold more potent than 6′-iodononivamide.
