19187-65-6

Upstream product

• 2816-57-1 2,6-dimethylcyclohexanone 
• 49805-43-8 2-methylcyclohexanone syn-oxime 
• 74-88-4 methyl iodide 

Downstream Products

• 57174-11-5 2,6-dimethyl-cyclohexanone semicarbazone 
• 24213-42-1 dl-cis,trans-2,6-dimethylcyclohexylamine 
• 75107-64-1 1-chloro-2,6-dimethyl-1-nitrocyclohexane 
• 19962-51-7 1,3-Dimethyl-2-nitro-cyclohexane 

Relevant academic research and scientific papers

SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS

The present disclosure relates to compounds of Formula (I): (I) and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

Photochemical rearrangement of N -chlorolactams: A route to N -heterocycles through concerted ring contraction

We report a novel ring contraction allowing the direct conversion of N-chlorolactams to their corresponding ring-contraction N-heterocycles upon photolysis. Results show that the rearrangement occurs with a variety of N-chlorolactams and that the greater the substitution at the migrating carbon, the greater the yield of product. Importantly, stereochemistry at the migrating carbon is conserved in the product. Rearranged products were isolated as their methyl carbamates in yields varying from 17% to 58%, with the major side product being the recyclable parent lactam.