191924-66-0Relevant articles and documents
A template for stabilizatgion of a peptide α-helix: Synthesis and evaluation of conformational effects by circular dichroism and NMR
Austin, Richard E.,Maplestone, Rachael A.,Sefler, Andrea M.,Liu, Kim,Hruzewicz, Witold N.,Liu, Corey W.,Cho, Ho S.,Wemmer, David E.,Bartlett, Paul A.
, p. 6461 - 6472 (2007/10/03)
The bicyclic diacid 1 was designed as a semi-rigid template for the hydrogen-bonding pattern of a peptide α-helix. The protected precursor 7 was synthesized in eight steps from tert-butyl 3,5-dimethoxybenzoate and linked to L-alanine and L-lactic acid to