191925-78-7

Upstream product

• 173950-07-7 Toluene-4-sulfonic acid 4-allyloxy-butyl ester 
• 162222-93-7 (1R,2R)-2-((2S,3S,4R,5R,6S)-3,4,5-Tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexanol 
• 1471-15-4 4-allyloxybutan-1-ol 
• 1072-86-2 (1R,2R)-trans-1,2-cyclohexanediol 
• 116514-50-2 ethyl 2,3,4-tri-O-benzyl-1-thio-β-L-fucopyranoside 

Relevant academic research and scientific papers

Malonic acid derivatives as sialyl Lewis X mimetics

Malonic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays and in vivo. The receptor binding affinity for E- and P-selectins of simple mimetics was found to be comparable to the potency of the tetrasaccharide sialyl Lewis X.

Synthesis of novel mimetics of the sialyl Lewis X determinant

Mimetics of the sialyl Lewis-X determinant in which at least one sugar domain is simulated by a di-, tri- or tetraalcohol unit have been synthesized. The inhibitory potency of these compounds for E- and P-selectin mediated cell adhesion has been evaluated in cell culture assays. The receptor binding affinity of the best of these mimetics was slightly higher than that of the natural oligosaccharide ligand sialyl Lewis X.