191936-91-1 Usage
General Description
HIV-1 trans-activator of transcription (Tat) is an 11kDa protein, which regulates HIV-1 gene expression at the level of transcription and protein synthesis. It is located in the nucleus of infected cells. HIV-1 Tat functions as a transcriptional activator for the synthesis of full-length viral RNA. It induces RNA splicing. Tat is an RNA binding protein, which particularly recognizes trans activator response element (TAR) from the HIV-1 RNA molecule.
Biochem/physiol Actions
Synthetic peptide that includes the sequence responsible for the cellular uptake of the human immunodeficiency virus-1 Tat protein, consisting of the polycationic region 49–57. The peptide is part of the protein transduction domain (PTD) and was shown to enable the introduction of nucleic acids into cells.
Check Digit Verification of cas no
The CAS Registry Mumber 191936-91-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,9,3 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 191936-91:
(8*1)+(7*9)+(6*1)+(5*9)+(4*3)+(3*6)+(2*9)+(1*1)=171
171 % 10 = 1
So 191936-91-1 is a valid CAS Registry Number.
191936-91-1Relevant articles and documents
Selective binding of TAR RNA by a Tat-derived β-peptide
Gelman, Michael A.,Richter, Sara,Cao, Hong,Umezawa, Naoki,Gellman, Samuel H.,Rana, Tariq M.
, p. 3563 - 3565 (2003)
(Equation presented) The interaction between the HIV-1 Tat protein and the TAR RNA element in the nascent viral genomic transcript is required for viral replication. An 11-residue β-peptide (1), an all-β homologue of the Arg-rich region Tat 47-57, binds T
