191993-86-9Relevant academic research and scientific papers
Hepatitis C Virus Inhibitors
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Paragraph 0318; 0321, (2015/11/02)
Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
An experimental and theoretical study on free ligand conformational preferences and enantioselectivity relationship for the asymmetric addition of diethylzinc to benzaldehyde
Wang, Min-Can,Liu, Zhi-kang,Li, Song,Ding, Xue,Li, Yuan,Tang, Ming-Sheng
experimental part, p. 486 - 493 (2010/06/20)
An experimental and theoretical study on free ligand conformational preferences and enantioselectivity relationship has been described for the asymmetric addition of diethylzinc to benzaldehyde. The results show that a correlation must exist between the ground-state ligand conformational populations and the observed ee values in this reaction. As the populations of the free ligand conformation (the desired conformation) in favor of the improvement of the reaction enantioselectivity increase, so does the reaction enantioselectivity. However, the desired conformation must not be the preferred one of the ground-state ligand. This conformation-enantioselectivity relationship is well explained based on a zinc amino-alkoxide (a true asymmetric catalyst). The final synthesis and assessment of the new chiral catalyst in the asymmetric addition of Et2Zn to benzaldehyde revealed that this necessary relationship guided our design of highly enantioselective ligands or rational improvement of existing ligands by means of knowledge of conformational analysis.
A convenient method of preparing optically active (S)-N-tritylaziridine- 2-carboxylate esters from (S)-β-haloamino acids
Kato, Yasuo,Fukumoto, Kenji
, p. 245 - 246 (2007/10/03)
A convenient method of preparing optically active (S)-N-tritylaziridine- 2-carboxylate esters via intramolecular cyclization of (S)-N-trityl-β- haloamino acid esters is described.
Synthesis of natural and non natural orthogonally protected lanthionines from N-tritylserine and allo-threonine derivatives
Dugave, Christophe,Menez, Andre
, p. 1453 - 1465 (2007/10/03)
The reactivity of electrophiles derived from N-tritylserine, threonine and allothreonine esters toward a selection of nucleophiles was investigated. Best yields from substitution products were obtained with N-trityliodoalanine and soft nucleophiles such a
