192003-01-3 Usage
Uses
Used in Biochemical Research:
L-BETA-HOMOTRYPTOPHAN HYDROCHLORIDE is used as a research tool for studying the structure and function of proteins and enzymes that interact with tryptophan. Its modified beta position allows for the investigation of the effects of structural changes on protein binding and activity.
Used in Pharmaceutical Applications:
L-BETA-HOMOTRYPTOPHAN HYDROCHLORIDE is used as a potential therapeutic agent for neurological and psychiatric disorders. Its unique structure and interactions may offer new avenues for the treatment of these conditions, providing an alternative to traditional medications.
Used in Protein Synthesis and Metabolism Studies:
L-BETA-HOMOTRYPTOPHAN HYDROCHLORIDE is utilized in research to understand its role in protein synthesis and metabolism. This knowledge can contribute to the development of new therapies and interventions for various diseases and conditions related to protein function.
Used in Drug Development:
L-BETA-HOMOTRYPTOPHAN HYDROCHLORIDE is employed in the development of new drugs targeting specific biological pathways and mechanisms. Its unique properties and interactions with proteins and enzymes make it a valuable compound for designing novel therapeutic agents.
Used in Laboratory and Industrial Settings:
L-BETA-HOMOTRYPTOPHAN HYDROCHLORIDE is used in various laboratory and industrial applications, including the synthesis of complex organic compounds, the development of analytical methods for detecting tryptophan and its derivatives, and the production of pharmaceuticals and other bioactive compounds. Proper safety measures and handling protocols are crucial to ensure the safe use of this chemical compound in these settings.
Check Digit Verification of cas no
The CAS Registry Mumber 192003-01-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,0,0 and 3 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 192003-01:
(8*1)+(7*9)+(6*2)+(5*0)+(4*0)+(3*3)+(2*0)+(1*1)=93
93 % 10 = 3
So 192003-01-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O2/c13-9(6-12(15)16)5-8-7-14-11-4-2-1-3-10(8)11/h1-4,7,9,14H,5-6,13H2,(H,15,16)/t9-/m0/s1
192003-01-3Relevant academic research and scientific papers
Design and synthesis of tryptophan containing dipeptide derivatives as formyl peptide receptor 1 antagonist
Hwang, Tsong-Long,Hung, Chih-Hao,Hsu, Ching-Yun,Huang, Yin-Ting,Tsai, Yu-Chi,Hsieh, Pei-Wen
, p. 3742 - 3755 (2013/06/27)
Our previous studies identified an Fmoc-(S,R)-tryptophan-containing dipeptide derivative, 1, which selectively inhibited neutrophil elastase release induced by formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) in human neutrophils. In an attempt to improve pharmacological activity, a series of tryptophan-containing dipeptides were synthesized and their pharmacological activities were investigated in human neutrophils. Of these, five compounds 3, 6, 19a, 24a, and 24b exhibited potent and dual inhibitory effects on FMLP-induced superoxide anion (O2-) generation and neutrophil elastase release in neutrophils with IC50 values of 0.23/0.60, 1.88/2.47, 1.87/3.60, 0.12/0.37, and 1.32/1.03 μM, respectively. Further studies indicated that inhibition of superoxide production in human neutrophils by these dipeptides was associated with the selective inhibition of formyl peptide receptor 1 (FPR1). Furthermore, the results of structure-activity relationship studies concluded that the fragment N-benzoyl-Trp-Phe-OMe (3) was most suitable as a core structure for interaction with FPR1, and may be approved as a lead for the development of new drugs in the treatment of neutrophilic inflammatory diseases. As some of the synthesized compounds exhibited separable conformational isomers, and showed diverse bioactivities, the conformation analysis of these compounds is also discussed herein. The Royal Society of Chemistry 2013.
