192046-36-9

Upstream product

• 75755-40-7 2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine 
• 69-72-7 salicylic acid 

Downstream Products

• 128396-72-5 2-(2-hydroxybenzoyl)-amino-2-methylpropionic acid 
• 192046-69-8 2-Hydroxy-N-(1-methyl-1-{1-methyl-1-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-benzamide 
• 192046-42-7 2-Hydroxy-N-{1-methyl-1-[1-(methyl-phenyl-carbamoyl)-cyclopentylcarbamoyl]-ethyl}-benzamide 
• 192046-41-6 2-Hydroxy-N-{1-methyl-1-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-ethyl}-benzamide 
• 192046-66-5 2-[2-(2-Hydroxy-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionic acid 

Relevant academic research and scientific papers

Synthesis of cyclic depsipeptides and peptides via direct amide cyclization

The 2,2-disubstituted 2H-azirin-3-amines 7 (2,2-disubstituted 3-amino-2H-azirines) were used as amino-acid synthons in the preparation of medium-sized cyclic depsipeptides and peptides derived from salicylic acids 6 and anthranilic acid 19, respectively.

14-Membered cyclodepsipeptides with alternating β-hydroxy and α-amino acids by cyclodimerization

The cyclodimerization (twinning) of β-hydroxy acid amides of type 1 under 'direct amide cyclization' (DAC) conditions is described. Although other coupling methods also gave moderate results, best yields were obtained via DAC, reaching 88% for the cyclodi