192065-56-8

Basic information

• Product Name: 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
• Synonyms: 4-(8-Methyl-9H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d][1,2]diazepin-5-yl)aniline hydrochloride;1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-5H-2,3-BENZODIAZEPINE HYDROCHLORIDE;GYKI 52466 (HCl salt);GYKI 52466 hydrochloride,1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
• CAS NO: 192065-56-8
• Molecular Formula: C17H15N3O2HCl
• Molecular Weight: 329.78
• Mol File: 192065-56-8.mol
• Article Data: 0

Chemical Properties

• Appearance: yellow/
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO: soluble0.39mg/mL
• CAS DataBase Reference: 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride(192065-56-8)
• EPA Substance Registry System: 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride(192065-56-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36
• WGK Germany: 3
• Hazardous Substances Data: 192065-56-8(Hazardous Substances Data)

Usage

Description

1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride, also known as GYKI 52466 hydrochloride, is a synthetic compound that acts as a selective antagonist for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. It is characterized by its unique chemical structure, which includes an aminophenyl group, a methyl group, and methylenedioxy bridges. 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride has been widely studied for its potential applications in various fields, particularly in the study of neurobiology and the development of therapeutic agents.
Used in Pharmaceutical Industry:
1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride is used as a research tool for studying the function of glutamate receptors in the central nervous system. Its ability to selectively block AMPA receptors makes it a valuable compound for investigating the role of these receptors in various neurological processes and disorders.
Used in Neurobiological Research:
1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride is used as an AMPA receptor selective antagonist in cell viability assays to evaluate the specificity of kainate (KA) effect on cerebellar granule cells (CGCs). This application helps researchers understand the mechanisms underlying the actions of excitatory neurotransmitters and their role in neuronal survival and death.
Used in Neurodegenerative Disease Studies:
1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride is used as an AMPA blocker to study the function of glutamate in neuroadapted sindbis virus (NSV)-induced motor neuron death. This application aids in the investigation of the role of glutamate receptors in motor neuron diseases and the potential development of therapeutic agents for their treatment.

Biochem/physiol Actions

GYKI 52466 serves as an antagonist of several processes, mediated by glutamate.