192070-45-4Relevant articles and documents
A second-generation synthesis of scalemic 3,5,5-trisubstituted pyrrolin-4-ones: Incorporation of functionalized amino acid side-chains
Smith III, Amos B.,Benowitz, Andrew B.,Favor, David A.,Sprengeler, Paul A.,Hirschmann, Ralph
, p. 3809 - 3812 (2007/10/03)
To access mimics of peptide β-strands (1), scalemic 3,5,5-trisubstituted pyrrolin-4-ones bearing the tyrosine, serine, and lysine side-chains have been generated via cyclization of metalated imino esters and deprotection. The functionalized imino esters were prepared by asymmetric alkylation of a common oxazolidinone precursor (2) derived from L-rhenylglycine.