192121-58-7Relevant academic research and scientific papers
A study of the conjugate addition of thionucleophiles to 2(5H)-furanones
Busque, Felix,De March, Pedro,Figueredo, Marta,Font, Josep,Gonzalez, Lluisa
, p. 1492 - 1499 (2004)
Several new 4-thio-4,5-dihydro-2(3H)-furanones were prepared by the conjugate addition reactions of different thioacids, dithioacids, xanthates and dithiocarbamates to 2(5H)-furanones. When 5-methyl-2(5H)-furanone was used as the electrophilic substrate, the reaction was diastereoselective affording exclusively the cis-α,β-disubstituted butanolides. Some adducts were selectively hydrolysed to deliver a free thiol functionality. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
