192130-34-0

Basic information

• Product Name: 4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: BUTTPARK 90\06-05;CHEMBRDG-BB 4004160;1-BOC-4-(2-AMINOETHYL)PIPERAZINE;4-N-(2-AMINOETHYL)-1-N-BOC-PIPERAZINE;4-(2-AMINO-ETHYL)-1-BOC-PIPERAZINE;4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(2-AMINOETHYL)PIPERAZINE, N1-BOC PROTECTED;TERT-BUTYL 4-(2-AMINOETHYL)PIPERAZINE-1-CARBOXYLATE
• CAS NO: 192130-34-0
• Molecular Formula: C₁₁H₂₃N₃O₂
• Molecular Weight: 229.32
• Product Categories: pharmacetical;piperazines
• Mol File: 192130-34-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 36-41°C
• Boiling Point: 319.4 °C at 760 mmHg
• Flash Point: >198℃
• Appearance: Oil
• Density: 1.056 g/cm³
• Vapor Pressure: 0.000339mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 10.11±0.10(Predicted)
• CAS DataBase Reference: 4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(192130-34-0)
• EPA Substance Registry System: 4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(192130-34-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 192130-34-0(Hazardous Substances Data)

Usage

General Description

4-(2-amino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C11H22N4O2. It is a tert-butyl ester derivative of piperazine-1-carboxylic acid, which contains an aminoethyl group. It is often used as a building block in the synthesis of pharmaceuticals and other organic compounds. This chemical has been studied for its potential as a corrosion inhibitor, antioxidant, and as a component in drug delivery systems. It has also shown potential as a ligand in coordination chemistry, as well as in the synthesis of bioactive heterocycles.

InChI:InChI=1/C11H23N3O2/c1-11(2,3)16-10(15)14-8-6-13(5-4-12)7-9-14/h4-9,12H2,1-3H3/p+2

Upstream product

• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 227776-28-5 tert-butyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethyl)piperazine-1-carboxylate 
• 911415-27-5 4-methyl-N-(2-(piperazin-1-yl)ethyl)pentan-2-imine 
• 882307-62-2 C₁₈H₂₇N₃O₂ 
• 100450-84-8 N-[phenylmethylidene]-2-piperazin-1-ylethanamine 
• 140-31-8 aminoethylpiperazine 
• 1108149-22-9 4-[2-(trifluoroacetylamino)ethyl]piperazine-1-carboxylic acid tert-butyl ester 
• 24948-82-1 N-chloroethylamine 

Downstream Products

• 1401333-83-2 C₂₃H₃₁N₃O₂ 
• 1401333-84-3 C₂₁H₂₆FN₃O 
• 1401333-85-4 C₂₁H₂₅Cl₂N₃O 
• 1401333-86-5 C₂₃H₃₁N₃O 
• 1401333-87-6 C₂₄H₃₃N₃O 
• 1401333-88-7 C₂₄H₃₃N₃O₂ 
• 1401333-89-8 C₂₂H₂₈FN₃O 
• 1401333-90-1 C₂₂H₂₇Cl₂N₃O 
• 1235230-54-2 C₁₉H₂₉N₃O₃ 
• 1401333-75-2 C₂₀H₃₁N₃O₃ 
• 1234831-41-4 C₂₀H₃₁N₃O₄ 
• 1235659-77-4 C₁₈H₂₅Cl₂N₃O₃ 
• 318257-73-7 4-Chloro-2-methoxy-N-[2-(1-piperazinyl)ethyl]benzamide trifluoroacetate 
• 318257-69-1 tert-Butyl 4-[2-({4-chloro-2-[2-(dimethylamino)-2-oxoethoxy]benzoyl}amino)ethyl]-1-piperazinecarboxylate 

Relevant articles and documents

PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST

Disclosed herein is a pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as an A2A receptor antagonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as an A2A receptor antagonist.

CINNAMIC ACID AMIDE DERIVATIVE

The present invention provides a cinnamic acid amide derivative having an excellent analgesic action. The cinnamic acid amide derivative of the present invention is a compound showing excellent analgesic actions to not only a nociceptive pain model animal but also a neuropathic pain model animal, which is very useful as an agent for treating various pain diseases showing acute or chronic pains or neuropathic pains.

The design and synthesis of 1,4-substituted piperazine derivatives as triple reuptake inhibitors

Novel 1,4-substituted piperazine derivatives 5, Series A and B were designed by fragment analysis and molecular modification of 4 selected piperazine-containing compounds which possess antidepressant activity. We synthesized new 39 analogues of Series A and 10 compounds of Series B, respectively. The antidepressant screening against DA, NE, and serotonin neurotransmitter uptake inhibition was carried out using the Neurotransmitter Transporter Uptake Assay Kit. The compounds in Series B showed relatively higher reuptake inhibitory activity for SERT, NET, and DAT than those in Series A. The length of spacer between the central piperazine core and the terminal phenyl ring substituted at the piperazine ring in Series B seems to exert an important role in the activity.