192132-77-7

Basic information

• Product Name: 2-(2-(tert-butoxycarbonylamino)ethoxy)ethyl 4-methylbenzenesulfonate
• Synonyms: 2-(2-(tert-butoxycarbonylamino)ethoxy)ethyl 4-methylbenzenesulfonate
• CAS NO: 192132-77-7
• Molecular Weight: 359.444
• Mol File: 192132-77-7.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: 2-(2-(tert-butoxycarbonylamino)ethoxy)ethyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(tert-butoxycarbonylamino)ethoxy)ethyl 4-methylbenzenesulfonate(192132-77-7)
• EPA Substance Registry System: 2-(2-(tert-butoxycarbonylamino)ethoxy)ethyl 4-methylbenzenesulfonate(192132-77-7)

Safety Data

• Hazardous Substances Data: 192132-77-7(Hazardous Substances Data)

Usage

Type of compound

sulfonate ester

Use

protecting group for amines in organic synthesis and chemical reactions

tert-butoxycarbonyl (Boc) group

commonly used to protect amine functionality in organic synthesis

2-(2-hydroxyethoxy)ethyl group

attached to the Boc group

4-methylbenzenesulfonate group

attached to the 2-(2-hydroxyethoxy)ethyl group

Importance

protects amine groups of a molecule during chemical reactions

Applications

synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

Upstream product

• 139115-91-6 2-(2-tert-butyloxycarbonylaminoethoxy)ethanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 959690-79-0 tert-butyl 2,2'-[2,2'-(2,5-diiodo-1,4-phenylene)bis(oxy)bis(ethane-2,1-diyl)]bis(oxy)bis(ethane-2,1-diyl)dicarbamate 
• 629626-40-0 2-(N-tert-butoxycarbonyl-2-aminoethoxy)-1-iodoethane 
• 1618136-59-6 C₂₇H₃₂N₃O₅⁽¹⁺⁾*C₇H₇O₃S^(1-) 
• 1618136-63-2 C₂₆H₃₂N₃O₃⁽¹⁺⁾*C₇H₇O₃S^(1-) 
• 1618136-67-6 C₂₇H₃₄N₃O₄⁽¹⁺⁾*C₇H₇O₃S^(1-) 

Relevant articles and documents

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TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.

HMG-COA REDUCTASE DEGRADATION INDUCING COMPOUND

The present invention relates HMG-CoA reductase degradation inducing compounds. Specifically, the present invention relates a bifunctional compound in which a HMG-CoA reductase binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention also relates a method for preparing the compounds, and a method for degradation of HMG-CoA reducatase using the compounds, as well as use for prevention or treatment of HMG-CoA reductase related diseases using the compounds.