19218-86-1Relevant academic research and scientific papers
Facile synthesis of indolo[3,2-a]carbazoles via Pd-catalyzed twofold oxidative cyclization
Yang, Chao,Lin, Kai,Huang, Lan,Pan, Wei-Dong,Liu, Sheng
, p. 2490 - 2494 (2016)
A rapid and efficient route has been developed for the synthesis of 9-methoxycarbonylindolo[3,2-a]carbazole derivatives. The key steps in this approach involved an aromatic amination and an oxidative biaryl coupling. Via the present route, indolo[3,2-a]carbazole derivatives are available in 3-4 steps based on commercially available starting materials.
Tetradentate cyclometalated platinum complexes containing 9,10-dihydroacridine and its analogues
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Page/Page column 296; 297; 298; 301, (2018/04/19)
Platinum complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having the following structure:
Tetradentate Cyclometalated Platinum Complexes Containing 9,10-Dihydroacridine And Its Analogues
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, (2015/12/23)
Platinum complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having the following structure:
Sc(OTf)3-catalyzed dehydrogenative cyclization for synthesis of N-methylacridones
Li, Xi-An,Wang, Hong-Li,Yang, Shang-Dong
supporting information, p. 1794 - 1797 (2013/05/23)
A novel method has been developed for the synthesis of substituted N-methylacridones from 2-(N-methyl-N-phenylamino)benzaldehydes via dehydrogenative cyclization. This transformation involves two primary processes: the aldehyde first coordinates with Sc(OTf)3 and induces the aromatic electrophilic substitution (SEAr) reaction to form the active intermediate N-methyl-acridin-9-ol, which is then quickly oxidized in situ to afford the acridones. Furthermore, the procedure involved is both environmental friendly and atom efficient; H2O is the only byproduct in this reaction.
Synthesis and biological evaluation of radioiodinated quinacrine-based derivatives for SPECT imaging of Aβ plaques
Fuchigami, Takeshi,Kobashi, Nobuya,Haratake, Mamoru,Kawasaki, Masao,Nakayama, Morio
, p. 469 - 478 (2013/04/10)
The aim of the present study was to characterize the binding property of quinacrine-based acridine derivatives for Aβ plaques and to evaluate this series of compounds as Aβ imaging probes. Quinacrine clearly stained Aβ plaques in the brain sections of Aβ
Palladium- and copper-catalyzed site selective monoamination of dibromobenzoic acid
Houpis, Ioannis N.,Weerts, Koen,Nettekoven, Ulrike,Canters, Martine,Tan, Hongyu,Liu, Renmao,Wang, Youchu
supporting information; experimental part, p. 538 - 544 (2011/04/23)
The carboxylate anion has been used as a directing group in the aromatic amination of electronically equivalent aryl bromides to afford selective ortho-substituted derivatives (> 99:1 selectivity; 60-80% yield) in the case of copper(I) catalysis. The solvent, base and equivalents of base were important factors in the success of this reaction. Complementary selectivity was achieved with palladium catalysis where the para-substituted derivatives were produced selectively (> 99% selectivity, 70-80% yield).
Tricyclic heterocyclic derivatives
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, (2008/06/13)
The invention relates to tricyclic heterocyclic derivatives, or pharmaceutically-acceptable salts or in vivohydrolysable esters thereof, which possess anti-cancer activity. The invention also relates to processes for the manufacture of said tricyclic hete
