192182-26-6

Basic information

• Product Name: 2-[2-(2-p-Tolyl-1H-indol-3-yl)-ethyl]-isoindole-1,3-dione
• Synonyms: 2-[2-(2-p-Tolyl-1H-indol-3-yl)-ethyl]-isoindole-1,3-dione
• CAS NO: 192182-26-6
• Molecular Weight: 380.446
• Mol File: 192182-26-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[2-(2-p-Tolyl-1H-indol-3-yl)-ethyl]-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2-p-Tolyl-1H-indol-3-yl)-ethyl]-isoindole-1,3-dione(192182-26-6)
• EPA Substance Registry System: 2-[2-(2-p-Tolyl-1H-indol-3-yl)-ethyl]-isoindole-1,3-dione(192182-26-6)

Safety Data

• Hazardous Substances Data: 192182-26-6(Hazardous Substances Data)

Upstream product

• 15741-71-6 N-phthalimidotryptamine 
• 5720-05-8 4-methylphenylboronic acid 
• 192182-46-0 2-(2-(2-bromo-1H-indol-3-yl)ethyl)isoindoline-1,3-dione 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 61-54-1 tryptamine 

Relevant articles and documents

Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles

A nonpeptidyl GnRH receptor antagonist (1), with a unique 2-arylindole core, was identified through the Merck in-house screening for binding affinity on the rat GnRH receptor. SAR studies directed toward the alkoxy-ethanolamine and 2-aryl groups resulted in a simpler lead structure with improved activity. This compound 50 exhibits a 60-fold improvement in binding activity over our initial lead 1.