192182-56-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Isoquinolineboronic acid is used as a reactant for the preparation of selective steroid-11β-hydroxylase (CYP11B1) inhibitors, which are crucial for the treatment of cortisol-dependent diseases.
Used in Organic Synthesis:
4-Isoquinolineboronic acid is used as a reactant for the preparation of tetrabutylammonium trifluoroborates, which are useful in various organic synthesis processes.
Used in Medicinal Chemistry:
4-Isoquinolineboronic acid is used as a reactant for the synthesis of heteroaryl substituted tetrahydropyrroloijquinolinone derivatives, which act as aldosterone synthase inhibitors, and for the synthesis of aminoarylpyridazines, which are selective CB2 agonists for the treatment of inflammatory pain.
Used in Chemical Research:
4-Isoquinolineboronic acid is used as a reactant for the preparation of acyl substituted indoles via palladium-catalyzed domino coupling/carbonylation/Suzuki coupling of dibromoethenylanilines, and for the synthesis of antagonists of bacterial quorum sensing.
Used in Cross-Coupling Reactions:
4-Isoquinolineboronic acid is used in the preparation of potassium heteroaryl trifluoroborates from boronic acids, which serve as coupling partners with various aryl and heteroaryl halides in Suzuki-Miyaura cross-coupling reactions, a widely used method in organic synthesis for the formation of carbon-carbon bonds.

InChI:InChI=1/C9H8BNO2/c12-10(13)9-6-11-5-7-3-1-2-4-8(7)9/h1-6,12-13H

Upstream product

• 1532-97-4 4-bromoisoquinoline 
• 5419-55-6 Triisopropyl borate 
• 109-72-8 n-butyllithium 

Downstream Products

• 1054314-77-0 4-[3-(4-methoxybenzyl)naphthalen-2-yl]isoquinoline 
• 1054314-78-1 4-[6-methoxy-3-(4-methoxybenzyl)naphthalen-2-yl]isoquinoline 
• 20377-03-1 4-azidoisoquinoline 
• 1373310-92-9 4-((6-phenylpyridin-3-yl)methyl)isoquinoline 
• 1610790-52-7 C₁₆H₁₁N₃ 
• 106510-95-6 4-(phenylthio)isoquinoline 
• 1025717-45-6 4-(isoquinolin-4-yl)-N-(2-methyl-5-nitrophenyl)pyrimidin-2-amine 
• 832696-14-7 3-(4-aminophenyl)-7-(4-isoquinolinyl)thieno[3,2-c]pyridin-4-amine 

Relevant academic research and scientific papers

A remarkable divergent fluorescence response to epimeric monosaccharides by an isoquinoline-derived diboronate

Herein we report a new boronic acid fluorescent sensor based on 4-isoquinolineboronic acid that has a fluorescent divergent response biologically relevant monosaccharides, glucose and galactose. By analyzing the interactions of this sensor with several alternate sugar forms we have been able to determine how the boronic acid selects diols for binding and how such a molecule could have a positive and negative fluorescent response to two very similar hexoses.

Pyrrolopyrimidines and Pyrrolopyridines

Compounds of formula I in free or salt or solvate form, wherein X, T1, T3 and T4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Inhibition of serotonin reuptake

This invention provides 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]oct-2-enes and 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]octanes which are useful for the inhibition of serotonin reuptake in mammals.

Azabicyclic inhibitors of serotonin reuptake

This invention provides 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]oct-2-enes and 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]octanes of furmula (I) which are useful for the inhibition of serotonin reuptake in mammals. whereA-B is -C=CH- or -CH-CH2/s