192182-65-3Relevant academic research and scientific papers
Synthesis and structure-activity relationships of 3-aryloxindoles: A new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties
Hewawasam, Piyasena,Erway, Matthew,Moon, Sandra L.,Knipe, Jay,Weiner, Harvey,Boissard, Christopher G.,Post-Munson, Debra J.,Gao, Qi,Huang, Stella,Gribkoff, Valentin K.,Meanwell, Nicholas A.
, p. 1487 - 1499 (2007/10/03)
A series of 3-aryloxindole derivatives were synthesized and evaluated as activators of the cloned maxi-K channel mSlo expressed in Xenopus laevis oocytes using electrophysiological methods. The most promising maxi-K openers to emerge from this study were
Discovery of a novel class of BK channel openers: Enantiospecific synthesis and BK channel opening activity of 3-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-3- hydroxy-6-(trifluoromethyl)-2H-indol-2-one
Hewawasam, Piyasena,Meanwell, Nicholas A.,Gribkoff, Valentin K.,Dworetzky, Steven I.,Boissard, Christopher G.
, p. 1255 - 1260 (2007/10/03)
3-Aryl-3-hydroxyindol-2-ones have been identified as a novel class of BK channel openers. Synthesis of both racemic and chiral 3-aryl-3-hydroxyindolones is described along with their electrophysiological evaluation as activators of the cloned BK channel m
