192187-67-0

Usage

Uses

Used in Pharmaceutical Industry:
(25R)-7α,26-dihydroxycholest-4-en-3-one is used as a pharmaceutical agent for its potential therapeutic effects. Its biological activities make it a promising candidate for the development of new drugs targeting various diseases.
Used in Research Applications:
(25R)-7α,26-dihydroxycholest-4-en-3-one is used as a research tool for studying the structure-activity relationships of oxygenated sterols and their biological effects. It helps researchers understand the molecular mechanisms underlying their therapeutic properties and identify potential drug targets.
Used in Nutraceutical Industry:
(25R)-7α,26-dihydroxycholest-4-en-3-one is used as a nutraceutical ingredient for its potential health benefits. Its biological activities suggest that it may have positive effects on human health when incorporated into dietary supplements or functional foods.
Used in Cosmetic Industry:
(25R)-7α,26-dihydroxycholest-4-en-3-one is used as an active ingredient in cosmetic products for its potential skin health benefits. Its biological activities may contribute to improved skin hydration, elasticity, and overall skin health.

Upstream product

• 144300-24-3 7alpha,27-OHC 
• 43204-21-3 (20R,25R)-cholest-5-ene-3β,26-diol 3,26-diacetate 
• 43204-20-2 (25R)-3β,26-diacetoxycholest-5-en-7-one 
• 240129-34-4 (25R)-cholest-5-ene-3β,7α,26-triol triacetate 
• 13095-61-9 (25R)-cholest-5-ene-3β,26-diol 
• 56792-59-7 (25R)-26-hydroxycholest-4-en-3-one 
• 71486-01-6 (25R)-26-hydroxycholest-4-en-3-one 26-acetate 
• 192187-72-7 (25R)-26-acetoxycholest-5-en-3β-ol 
• 192187-70-5 (25R)-3β-(tert-butyldimethylsilyloxy)cholest-5-en-26-ol 
• 192187-71-6 (25R)-26-(tert-butyldimethylsilyloxy)cholest-5-en-3β-ol 
• 192187-75-0 Acetic acid (2R,6R)-6-((8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-8,9,10,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-methyl-heptyl ester 
• 192187-74-9 Acetic acid (2R,6R)-6-((8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-heptyl ester 
• 97550-38-4 (8S,9S,10R,13R,14S,17R)-17-[(1R,5R)-6-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 192187-76-1 Acetic acid (2R,6R)-6-((6R,7S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-20-oxa-cyclopropa[6,7]cyclopenta[a]phenanthren-17-yl)-2-methyl-heptyl ester 

Relevant academic research and scientific papers

Synthesis of two marine natural products: The aglycones of pavoninin-1 and 2

The first syntheses of the aglycones of pavoninin-1 and 2 have been accomplished via the epoxide 12.

Sterol synthesis. Preparation and characterization of fluorinated and deuterated analogs of oxygenated derivatives of cholesterol

Oxygenated sterols, including both autoxidation products and sterol metabolites, have many important biological activities. Identification and quantitation of oxysterols by chromatographic and spectroscopic methods is greatly facilitated by the availability of authentic standards, and deuterated and fluorinated analogs are valuable as internal standards for quantitation. We describe the preparation, purification and characterization of 43 oxygenated sterols, including the 4β-hydroxy, 7α-hydroxy, 7β-hydroxy, 7-keto, and 19-hydroxy derivatives of cholesterol and their analogs with 25,26,26,26,27,27,27-heptafluoro (F7) and 26,26,26,27,27,27-hexadeuterio (d6) substitution. The 7α-hydroxy, 7β-hydroxy, and 7-keto derivatives of (25R)-cholest-5-ene-3β,26-diol (1d) and their 16,16-dideuterio analogs were also prepared. These d2-26-hydroxysterols and [16,16-2H2]-(25R)-cholest-5-ene-3β,26-diol (1e) were synthesized from [16,16-2H2]-(25R)-cholest-5-ene-3β,26-diol diacetate (2e), which can be prepared from diosgenin. The highly specific deuterium incorporation at C-16 in 1e and 2e should be useful in mass spectral analysis of 26-hydroxycholesterol samples by isotope dilution methods. The Δ5-3β,7α,26- and Δ5-3β,7β,26-triols were regioselectively oxidized/isomerized to the corresponding Δ4-3-ketosteroids with cholesterol oxidase. Also described are 5,6α-epoxy-5α-cholestan-3β-ol, its 5β,6β-isomer, cholestane-3β,5α,6β-triol, their F7 and d6 derivatives, and d3-25-hydroxycholesterol, which was prepared from 3β-acetoxy-27-norcholest-5-en-25-one (30). The 43 oxysterols and most synthetic intermediates were isolated in high purity and characterized by chromatographic and spectroscopic methods, including mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Detailed mass spectral assignments are presented, and 1H NMR stereochemical assignments are derived for the C-19 protons of 19-hydroxysterols and for the side chain protons of 30. Copyright (C) 1999 Elsevier Science Ireland Ltd.