192199-27-2Relevant academic research and scientific papers
Diastereoselective alkylation of 8-phenylmenthyl 2- methylacetoacetate. Preparation of enantiomerically pure 4,4-disubstituted 2-pyrazolin-5-ones
Moreno-Manas, Marcial,Sebastian, Rosa M.,Vallribera, Adelina,Molins, Elies,Espinosa, Enrique
, p. 1525 - 1527 (1997)
Alkylation of (1R,3R,4S)-8-phenylmenthyl 2-methylacetoacetate with alkyl halides affords 2-alkyl-2-methylacetoacetates in diastereomeric ratios 72:28 to 85:15. The major R (at C-α) diastereoisomers are converted into enantiopure 4,4-disubstituted 2-pyrazolin-5-ones with recovery of the chiral inductor.
