192204-31-2

Basic information

• Product Name: (S)-4-{2-[(S)-4-(2-Amino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyrylamino]-phenyl}-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester
• Synonyms: (S)-4-{2-[(S)-4-(2-Amino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyrylamino]-phenyl}-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester
• CAS NO: 192204-31-2
• Molecular Weight: 662.7
• Mol File: 192204-31-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-{2-[(S)-4-(2-Amino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyrylamino]-phenyl}-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-{2-[(S)-4-(2-Amino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyrylamino]-phenyl}-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester(192204-31-2)
• EPA Substance Registry System: (S)-4-{2-[(S)-4-(2-Amino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyrylamino]-phenyl}-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester(192204-31-2)

Safety Data

• Hazardous Substances Data: 192204-31-2(Hazardous Substances Data)

Upstream product

• 192204-29-8 (S)-4-(2-tert-Butoxycarbonylamino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid 
• 192204-27-6 (S)-4-(2-Amino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester 
• 192204-26-5 (S)-4-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-phenyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester 
• 192204-25-4 (S)-2-Ethylsulfanylmethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester 
• 192204-24-3 (S)-4-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-phenyl]-2-methoxymethoxy-butyric acid methyl ester 
• 1026868-52-9 (S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester 
• 192204-28-7 (S)-4-(2-tert-Butoxycarbonylamino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester 
• 192204-23-2 (S)-4-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-phenyl]-2-hydroxy-butyric acid methyl ester 
• 192204-30-1 (S)-4-{2-[(S)-4-(2-tert-Butoxycarbonylamino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyrylamino]-phenyl}-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester 

Relevant articles and documents

Stereoselective Synthesis of a Thymine Derivative of (S)-2-Hydroxy-4-(2-aminophenyl)butanoic Acid. A Novel Building Block for the Synthesis of Aromatic Peptidic Nucleic Acid Oligomers

The synthesis of a thymine derivative of (S)-2-hydroxy-4-(2-aminophenyl)butanoic acid, compound 1, was achieved in high enantiomeric purity. The acyclic pyrimidine analog (S)-1 is a useful building block for the synthesis of a novel class of oligomers, the aromatic peptide nucleic acids (APNA, Scheme 1). The APNA tetramer 18 was prepared from the amino acid monomer (S)-1 using classical peptide synthesis. UV absorption spectra and 1H NMR data of this tetramer suggested that base stacking interactions in the APNA oligomers may be favorable.