19221-36-4Relevant articles and documents
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Stevens et al.
, p. 4590,4592 (1955)
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The α-Chlorination of Aryl Ketones with Manganese(III) Acetate in the presence of Chloride Ion
Tsuruta, Takehiko,Harada, Tetsuya,Nishino, Hiroshi,Kurosawa, Kazu
, p. 142 - 145 (2007/10/02)
The reaction of 2-(4-methoxyphenyl)-4-chromanone with Mn(OAc)3 in the presence of LiCl gave 3,3-dichloro-2-(4-methoxyphenyl)-4-chromanone.The reactions of 2-phenyl-4-chromanone, 1-phenyl-1-propanone, 1,2-diphenylethanone, and 1-tetralone similarly yielded α,α-dichloro derivatives in good yields. 2,2,2-Trichloroacetophenones were obtained from 2,2-dichloroacetophenones, but in the absence of LiCl, 2,2-dichloroacetophenones gave 2,2,3,3-tetrachloro-1,4-butanediones.KCl, NaCl, NH4Cl,AlCl3, and CaCl2 were also employed as the Cl- ion source.Synthetic applicability and the reaction mechanisms are discussed briefly.