192213-12-0Relevant articles and documents
Total synthesis of parvaquone and the serendipitous discovery of a novel chromium-mediated method for β-lactone formation
Harrity, Joseph P. A.,Kerr, William J.,Middlemiss, David,Scott, James S.
, p. 219 - 227 (1997)
During attempts to synthesise the 2-hydroxy-1,4-naphthoquinone, parvaquone, 1, a novel chromium-mediated method for the synthesis of functionalised β-lactones from propargyl alcohols has been discovered. Additionally, using both dry state and ultrasound conditions, the total synthesis of parvaquone (1) has been achieved; the most efficient techniques deliver this target compound in up to 46% overall yield over, as low as, two synthetic processes.