192311-33-4

Upstream product

• 501-53-1 benzyl chloroformate 
• 192311-30-1 2-[(Benzyloxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-pent-4-enoic acid ethyl ester 
• 192311-42-5 4-Allyl-3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester 
• 192311-31-2 4-Allyl-3-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester 
• 478488-15-2 4-[3-(tert-butyl-dimethyl-silanyloxy)-3-methoxycarbonyl-allyl]-4,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester 

Relevant academic research and scientific papers

Stereocontrolled synthesis of triazacyclopenta[cd]pentalenes by intramolecular 1,3-dipolar cycloaddition reactions of azomethine imines

The construction of triazacyclopenta[cd]pentalene diesters 6 by the reaction of dihydropyrrole α-ketoesters 3 with acylated hydrazines was evaluated further as a potential central strategic step in the total syntheses of complex guanidine alkaloids such as palau'amine and styloguanidine. Successful cyclocondensations were realized with acid-stable 2,2,2-trichloroethyl carbazate and thiosemicarbazide, but not tert-butyl carbazate. The substituent on the pyrrolidine nitrogen can be alkoxycarbonyl, sulfonyl, or an N-alkyl-2-acylpyrrole group. Siloxy substitution at C1 of the α-ketoester side chain is also tolerated.