192314-84-4 Usage
Uses
Used in Pharmaceutical Research:
Cytidine, 2',3'-dideoxy-3'-(hydroxymethyl)-5'-O-(triphenylmethyl)is used as a research compound for the development of new nucleoside analogs with potential therapeutic applications. Its unique structure allows for the exploration of its interactions with biological systems and the assessment of its efficacy in treating various diseases.
Used in Molecular Biology:
In molecular biology, Cytidine, 2',3'-dideoxy-3'-(hydroxymethyl)-5'-O-(triphenylmethyl)is used as a tool to study the structure and function of nucleic acids. Its modified sugar and protected hydroxyl group enable researchers to investigate the role of cytidine in DNA and RNA and to understand the mechanisms of nucleic acid synthesis and degradation.
Used in Drug Synthesis and Purification:
Cytidine, 2',3'-dideoxy-3'-(hydroxymethyl)-5'-O-(triphenylmethyl)is used as a protected intermediate in the synthesis and purification of nucleoside analogs. The triphenylmethyl group provides protection during chemical reactions, facilitating the production of desired compounds with improved yields and purity.
Check Digit Verification of cas no
The CAS Registry Mumber 192314-84-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,3,1 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 192314-84:
(8*1)+(7*9)+(6*2)+(5*3)+(4*1)+(3*4)+(2*8)+(1*4)=134
134 % 10 = 4
So 192314-84-4 is a valid CAS Registry Number.
192314-84-4Relevant academic research and scientific papers
Synthesis of 2',3'-dideoxy-3'-hydroxymethylcytidine; A unique antiviral nucleoside
Faul, Margaret M.,Huff, Bret E.,Dunlap, Steven E.,Frank, Scott A.,Fritz, James E.,Kaldor, Stephen W.,LeTourneau, Michael E.,Staszak, Michael A.,Ward, Jeffrey A.,Werner, John A.,Winneroski, Leonard L.
, p. 8085 - 8104 (2007/10/03)
The synthesis of 2',3'-dideoxy-3'-hydroxymethylcytidine 1 was accomplished using two different approaches. First, uridine and cytidine were used to prepare the key intermediate epoxides 15 and 31 which were opened with cyanide, deoxygenated by elimination to vinyl nitriles 17 and 36, and reduced by 1,4 hydride addition to the saturated nitriles 18 and 37. Secondly, a novel Rh-catalyzed hydroformylation reaction of 2',3'-didehydro-2',3'-dideoxycytidine 46 was used to prepare 1 in four steps. The attempted use of 2'-deoxyuridine and 2'-deoxycytidine to prepare 1 is also discussed.
