19232-43-0 Usage
Uses
Used in Bioconjugation and Fluorescent Labeling:
N-(4-Carboxy-3-hydroxyphenyl)maleimide is used as a reactive dye and labeling reagent for the bioconjugation and fluorescent labeling of proteins and other biomolecules. Its unique structure allows for specific interactions with target molecules, facilitating the attachment of labels or other functional groups.
Used in Synthesis of Fluorescent Dyes:
This maleimide derivative is utilized in the synthesis of fluorescent dyes, which are essential tools in various research areas, including cell biology, molecular biology, and biochemistry. The fluorescent properties of these dyes enable the visualization and tracking of biomolecules within biological systems.
Used in Organic Chemistry for Biomolecule Modification:
N-(4-Carboxy-3-hydroxyphenyl)maleimide serves as a reagent in organic chemistry for the modification of biomolecules. Its reactive nature allows for the introduction of new functional groups or the alteration of existing ones, enhancing the properties or functions of the biomolecules.
Used in Research and Industrial Applications:
Due to its diverse properties, N-(4-Carboxy-3-hydroxyphenyl)maleimide has the potential to be employed in a variety of research and industrial applications. Its ability to act as a reactive dye, labeling reagent, and a component in the synthesis of fluorescent dyes makes it a valuable asset in the development of new technologies and products in fields such as pharmaceuticals, diagnostics, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 19232-43-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,2,3 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 19232-43:
(7*1)+(6*9)+(5*2)+(4*3)+(3*2)+(2*4)+(1*3)=100
100 % 10 = 0
So 19232-43-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H7NO5/c13-8-5-6(1-2-7(8)11(16)17)12-9(14)3-4-10(12)15/h1-5,13H,(H,16,17)
19232-43-0Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41
Liu, Kun,Lu, Hong,Hou, Ling,Qi, Zhi,Teixeira, Cátia,Barbault, Florent,Fan, Bo-Tao,Liu, Shuwen,Jiang, Shibo,Xie, Lan
experimental part, p. 7843 - 7854 (2009/11/30)
On the basis of the structures of small-molecule hits targeting the HIV-1 gp41, N-(4-carboxy-3-hydroxy)phenyl-2,5-dimethylpyrrole (2, NB-2), and N-(3-carboxy-4-chloro)phenylpyrrole (A1, NB-64), 42 N-carboxyphenylpyrrole derivatives in two categories (A and B series) were designed and synthesized. We found that 11 compounds exhibited promising anti-HIV-1 activity at micromolar level and their antiviral activity was correlated with their inhibitory activity on gp41 six-helix bundle formation, suggesting that these compounds block HIV fusion and entry by disrupting gp41 core formation. The structure-activity relationship and molecular docking analysis revealed that the carboxyl group could interact with either Arg579 or Lys574 to form salt bridges and two methyl groups on the pyrrole ring were favorable for interaction with the residues in gp41 pocket. The most active compound, N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrrole (A12), partially occupied the deep hydrophobic pocket, suggesting that enlarging the molecular size of A12 could improve its binding affinity and anti-HIV-1 activity for further development as a small-molecule HIV fusion and entry inhibitor.
Synthesis and properties of a new selective bifunctional cross linking reagent
Trommer,Kolkenbrock,Pfeiderer
, p. 1455 - 1458 (2007/10/10)
A new bifunctional reagent, 2 hydroxy 4 maleimidobenzoylazide, has been synthesised to serve as a selective agent for the step wise cross linking of mercapto and amino functions of proteins. The optimal reaction conditions and rate constants fo this reagent have been determined using model substances.
