192330-70-4

Usage

Uses

Used in Pharmaceutical Research:
Uridine, 5-chloro-5'-O-[(4-methoxyphenyl)diphenylmethyl]is used as a research compound for exploring its potential biological activities and therapeutic applications. Its unique structure may offer insights into the development of new drugs and treatments.
Used in Nucleoside and RNA Biology Studies:
Uridine, 5-chloro-5'-O-[(4-methoxyphenyl)diphenylmethyl]is used as a research tool in the field of nucleoside and RNA biology, where it can help scientists understand the interactions and functions of RNA and its components.
Used in Medicinal Chemistry:
Uridine, 5-chloro-5'-O-[(4-methoxyphenyl)diphenylmethyl]is employed in medicinal chemistry to study the properties of compounds with similar structures, potentially leading to the discovery of new therapeutic agents.

Upstream product

• 1820-81-1 5-chlorouracil 
• 58-96-8 uridine 
• 2880-89-9 5-chlorouridine 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 3370-68-1 2',3',5'-tri-O-acetyl-5-chlorouridine 
• 4105-38-8 Tri-O-acetyluridine 

Downstream Products

• 2880-89-9 5-chlorouridine 

Relevant academic research and scientific papers

Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected d -Ribose

New, improved methods to access nucleosides are of general interest not only to organic chemists but to the greater scientific community as a whole due their key implications in life and disease. Current synthetic methods involve multistep procedures employing protected sugars in the glycosylation of nucleobases. Using modified Mitsunobu conditions, we report on the first direct glycosylation of purine and pyrimidine nucleobases with unprotected d-ribose to provide β-pyranosyl nucleosides and a one-pot strategy to yield β-furanosides from the heterocycle and 5-O-monoprotected d-ribose.

In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues

Following up on a hit that was identified in a large scale cell-based antiviral screening effort, a series of triphenylmethyl alkylated nucleoside analogues were synthesized and evaluated for their in vitro antiviral activities against the dengue virus (DENV) and the yellow fever virus (YFV). Hereto, trityl moieties were attached at various positions of the sugar ring combined with subtle variations of the heterocyclic base. Several triphenylmethyl modified nucleosides were uncovered being endowed with submicromolar in vitro antiviral activity against the YFV. The most selective inhibitor in this series was 3′,5′-bis-O-tritylated-5-chlorouridine (1b) affording a selectivity index of over 90, whereas the 3′,5′-bis-O-tritylated inosine congener (5b) displayed the highest activity, but proved more toxic. The finding of these lipophilic structures being endowed with high antiviral activity for flaviviruses, should stimulate the interest for further structureeactivity research.