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Usage

Uses

Used in Pharmaceutical Industry:
2-Cyano-4-nitropyridine is used as an intermediate in the synthesis of pharmaceuticals for its ability to create new chemical compounds with diverse properties, contributing to the development of innovative medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Cyano-4-nitropyridine is employed as a precursor in the production of agrochemicals, aiding in the development of effective and environmentally friendly pest control solutions.
Used in Dye Industry:
2-Cyano-4-nitropyridine is used as a key component in the manufacturing of dyes, providing a wide range of color options and enhancing the performance of dye products.
Used in Organic Synthesis:
As a versatile precursor, 2-Cyano-4-nitropyridine is utilized in the synthesis of various organic compounds, enabling the creation of novel chemical entities with unique properties and applications.
Safety Precautions:
It is crucial to handle 2-Cyano-4-nitropyridine with care, as it can be harmful if ingested, inhaled, or comes into contact with skin or eyes. Proper safety measures should be taken to minimize potential risks during its use and handling.

InChI:InChI=1/C6H3N3O2/c7-4-5-3-6(9(10)11)1-2-8-5/h1-3H

Upstream product

• 694-59-7 pyridine N-oxide 
• 1124-33-0 4-nitraminopyridine N-oxide 
• 77-78-1 dimethyl sulfate 
• 151-50-8 potassium cyanide 

Downstream Products

• 62020-02-4 4-nitro-pyridine-2-carboxylic acid amide 
• 1414851-50-5 3-carbobenzyloxy-6-(4-methoxypicolinoyl)-3,6-diazabicyclo[3.1.0]hexane 
• 1414851-92-5 diphenyl (1R,2R)-6-(4-methoxypicolinamido)cyclohex-3-enylphosphonate 
• 1426583-30-3 diphenyl (1S,2S)-6-(4-methoxypicolinamido)cyclohex-3-enylphosphonate 
• 1414851-94-7 diphenyl (2R,3R)-3-(4-methoxypicolinamido)-1,2,3,4-tetrahydronaphthalen-2-ylphosphonate 
• 1426583-28-9 diphenyl (2S,3S)-3-(4-methoxypicolinamido)-1,2,3,4-tetrahydronaphthalen-2-ylphosphonate 
• 1414851-95-8 diphenyl (1R,2R)-2-(4-methoxypicolinamido)cyclopentylphosphonate 
• 1426583-27-8 diphenyl (1S,2S)-2-(4-methoxypicolinamido)cyclopentylphosphonate 
• 1414851-96-9 diphenyl (3R,4R)-1-(benzyloxycarbonyl)-4-(4-methoxypicolinamido)pyrrolidin-3-ylphosphonate 
• 1426583-26-7 diphenyl (3S,4S)-1-(benzyloxycarbonyl)-4-(4-methoxypicolinamido)pyrrolidin-3-ylphosphonate 
• 1414851-97-0 diphenyl (2R,3R)-3-(4-methoxypicolinamido)butan-2-ylphosphonate 
• 1426582-59-3 diphenyl (2S,3S)-3-(4-methoxypicolinamido)butan-2-ylphosphonate 
• 1414851-99-2 diphenyl (4R,5R)-5-(4-methoxypicolinamido)octan-4-ylphosphonate 
• 1426582-46-8 diphenyl (4S,5S)-5-(4-methoxypicolinamido)octan-4-ylphosphonate 

Relevant academic research and scientific papers

A gas-phase study on the cyclometallation of a series of Cp*Ir(III) complexes bearing bidentate pyrimidine ligands

A concerted approach of synthesis and gas phase experiments characterizes the relative cyclometallation barriers of a series of cationic η5-Cp* iridium(III) compounds. The common feature of the investigated compounds is a bidentate N,N’-donor ligand possessing a pyridine site functionalized with a 5-butylpyrimidin-2-yl ring in the 2-position. In addition, the pyridine ring was functionalized with electron-donating or -withdrawing groups. The compounds were characterized by means of NMR and IR spectroscopy and elemental analysis. For the measurements of the relative barriers of the cyclometallation, collision-induced dissociation (CID) experiments were carried out, which revealed a clear dependence of the relative barriers from the nature and the position of the substituents at the pyridine ring could be worked out.

Cinchona alkaloid amides/dialkylzinc catalyzed enantioselective desymmetrization of aziridines with phosphites

The first highly enantioselective desymmetrization of aziridines with phosphites has been developed. Excellent yields and enantioselectivities were observed for the reaction with various aziridines using a new class of readily accessible chiral catalysts derived from 9-amino-9-deoxy-epi-cinchona alkaloids. In studies probing the reaction mechanism, we observed some complexes for the cinchona alkaloid amide-Zn(II) by ESI-MS analysis.

Single component N-O chelated arylnickel(II) complexes as ethene polymerisation and CO/ethene copolymerisation catalysts. Examples of ligand induced changes to the reaction pathway

Arylnickel(II) phosphine complexes containing substituted N-O bidentate ligands, of the type [NiR(N-O)L] [N-O = 4-nitropyridine-2-carboxylate (4-NO2-pyca), R = 0-tolyl, L = PPh3; N-O = 2-pyrazinecarboxylate (pyzca), R = 0-tolyl, L = PPh3; and N-O = 4-methoxypyridine-2-carboxylate (4-MeO-pyca), R = 0-tolyl, L = PPh3] have been prepared and characterised. Single crystal X-ray studies of the complexes [Ni(0-tolyl)(pyca)PPh3], 1, and the isomorphous analogue [Ni(0-tolyl)(4-NO2-pyca)PPh3], 3, show the expected square planar coordination about the nickel centres, with the pyridine nitrogens being trans to the phosphine ligand for both compounds. The coordination spheres of the two complexes are very similar, no elongation of the Ni-N bond for complex 3, which contains the 4-NO2-pyca ligand, being evident. In complex 3 the 0-tolyl ligand is disordered over two sites indicating the presence, in the solid state, of two conformers in which the 0-methyl groups of 0-tolyl are located to either side of the coordination plane. The complexes with substituted pyca ligands form single component catalysts for the conversion of ethene to high molecular weight polyethene and for the copolymerisation of ethene and carbon monoxide to polyketone under mild conditions. The nature of the product, whether predominantly high molecular weight polymer or a mixture of polymer and lower oligomer, is dependent on the basicity of the N-O chelate ligand. From an NMR study of the effect of added ethene on the complex [Ni(0-tolyl)(4-NO2-pyca)PPh3], a mechanism involving alkene promoted ligand dissociation is suggested.

Antipruritic composition

An antipruritic composition for an oral medicine, injection, and external medicine, comprising an effective amount of a chelated zinc (e.g., zinc picolinate) as an antipruritic agent.