192377-04-1

Basic information

• Product Name: L-Tryptophan, N-[[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]-, methyl ester
• CAS NO: 192377-04-1
• Molecular Formula: C26H23Cl2N3O3
• Molecular Weight: 496.393
• Mol File: 192377-04-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Tryptophan, N-[[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tryptophan, N-[[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]-, methyl ester(192377-04-1)
• EPA Substance Registry System: L-Tryptophan, N-[[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]-, methyl ester(192377-04-1)

Safety Data

• Hazardous Substances Data: 192377-04-1(Hazardous Substances Data)

Upstream product

• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 15307-86-5 [2-(2,6-dichloroanilino)phenyl]acetic acid 

Downstream Products

• 192377-11-0 2-[2-(2,6-Dichloro-phenylamino)-phenyl]-N-[(S)-1-hydrazinocarbonyl-2-(1H-indol-3-yl)-ethyl]-acetamide 

Relevant articles and documents

Studies on o-[2,6-dichlorophenyl-1-amino] phenyl acetic acid I. Synthesis, antiinflammatory, analgesic and ulcerogenic activities of some new amino acid conjugates

o-[2,6-Dichlorophenyl-1-amino]phenyl acetic acid (diclofenac) (I) reacted with some amino-acid esters, namely glycine, L-valine, L- diiodotyrosine and L-tryptophan through the active ester to give the corresponding o-[2,6-dichlorophenyl-1-amino]benzyl carboxy-N-amino acid ester of the type (IIa-d), respectively, which were hydrolysed in alkaline medium to yield the free amino acids (IIIa-d). Condensation of the latter compounds with hydrazine hydrate gave the corresponding acid hydrazides (IVa-d), which in turn were reacted with trimethoxybenzaldehyde to give the corresponding Schiff's bases (Va-d), respectively. The antiinflammatory, ulcerogenic and analgesic activities of the obtained compounds were also investigated.