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192391-48-3

192391-48-3

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192391-48-3 Usage

Description

ImmunoglobulinG2a, anti-(human CD20 (antigen)) (mouse monoclonal clone B1R1 g2a-chain), disulfide with mouse monoclonal clone B1R1 lx-chain, dimer, iodine-131I-labeled is a radioimmunotherapeutic antibody specifically designed for the treatment of CD20-positive, follicular non-Hodgkin's lymphoma (NHL) in patients whose disease is refractory to rituximab and has relapsed following chemotherapy. This antibody is produced in an antibiotic-free culture of mammalian cells and is composed of a dual-action therapy that combines the tumor-targeting ability of a cytotoxic monoclonal antibody and the therapeutic potential of radiation with patient-specific dosing.

Uses

Used in Oncology:
ImmunoglobulinG2a, anti-(human CD20 (antigen)) (mouse monoclonal clone B1R1 g2a-chain), disulfide with mouse monoclonal clone B1R1 lx-chain, dimer, iodine-131I-labeled is used as a radioimmunotherapeutic agent for the treatment of CD20-positive, follicular non-Hodgkin's lymphoma (NHL) in patients who have not responded to or have relapsed from rituximab therapy. The antibody targets the CD20 antigen on NHL cells, initiating an immune response to the cancer, while the radiolabeled antibody, 131I-labeled, delivers a dose of radiation directly to the tumor cells. This targeted approach allows for a continuous low dose rate of radiation to be delivered to the tumor site, with the dose rate initially increasing as the radiolabeled antibodies accumulate at the tumor site and then decreasing with the physical decay of the radioisotope and clearance from the body.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ImmunoglobulinG2a, anti-(human CD20 (antigen)) (mouse monoclonal clone B1R1 g2a-chain), disulfide with mouse monoclonal clone B1R1 lx-chain, dimer, iodine-131I-labeled is used for the development of novel drug delivery systems and therapeutic regimens for the treatment of non-Hodgkin's lymphoma. The antibody's unique properties, such as its tumor-targeting ability and the incorporation of radiation therapy, make it a valuable tool for researchers and pharmaceutical companies in the development of new cancer treatments.
Brand Name: Bexxar

Originator

Corixa (US)

Check Digit Verification of cas no

The CAS Registry Mumber 192391-48-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,3,9 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 192391-48:
(8*1)+(7*9)+(6*2)+(5*3)+(4*9)+(3*1)+(2*4)+(1*8)=153
153 % 10 = 3
So 192391-48-3 is a valid CAS Registry Number.

192391-48-3Upstream product

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