1924-75-0Relevant academic research and scientific papers
Palladium-catalyzed (Ullmann-type) homocoupling of aryl halides: A convenient and general synthesis of symmetrical biaryls via inter- and intramolecular coupling reactions
Hennings, D. David,Iwama, Tetsuo,Rawal, Viresh H.
, p. 1205 - 1208 (1999)
(matrix presented) A convenient new procedure is described for both inter-and intramolecular homocoupling of aryl halides (Ullmann reaction) using catalytic palladium in the presence of hydroquinone, a homogeneous reductant. Optimal conditions for the reductive coupling include the use of a 1:1 molar ratio of Pd(OAc)2 and As(o-tolyl)3 in catalytic amounts under basic conditions.
Palladium-catalyzed regiocontrolled domino synthesis of N-sulfonyl dihydrophenanthridines and dihydrodibenzo[c, e]azepines: Control over the formation of biaryl sultams in the intramolecular direct arylation
Laha, Joydev K.,Dayal, Neetu,Jain, Roli,Patel, Ketul
, p. 10899 - 10907 (2015/01/08)
A palladium-catalyzed domino N-benzylation/intramolecular direct arylation involving sulfonanilides and 2-bromobenzyl bromides has been developed for the first time, providing a workable access to N-sulfonyl dihydrophenanthridines in good to excellent yields. Under the optimized conditions, the formation of 5,6-dihydrophenanthridines was largely controlled over the formation of biaryl sultams containing a seven member ring. The optimized condition was found extendable to the regiocontrolled domino formation of N-sulfonyl-6,7-dihydro-5H-dibenzo[c,e]azepines over the biaryl sultam formation. Using an appropriate substrate, a biaryl sultam has been obtained exclusively.
