192448-69-4Relevant academic research and scientific papers
Chemoenzymatic synthesis and biological evaluation of (-)-conduramine C-4
Bellomo, Ana,Giacomini, Cecilia,Brena, Beatriz,Seoane, Gustavo,Gonzalez, David
, p. 3509 - 3518 (2007)
Previously unreported (-)-conduramine C-4 was synthesized in six steps from a bacterial bromobenzene metabolite in 23% overall yield. The chemoenzymatic route involved toluene dioxygenase dihydroxylation, β-epoxidation, epoxide ring-opening, Staudinger reduction, radical debromination, and Amberlite- catalyzed hydrolysis. (-)-Conduramine C-4 and other related compounds synthesised were assayed for galactosidase-activity inhibition against β-D-galactoside galactohidrolase isolated from Aspergillus oryzae. Copyright Taylor & Francis Group, LLC.
