19245-87-5

Basic information

• Product Name: AC-ALA-ALA-OH
• Synonyms: N-ACETYL-L-ALA-L-ALA;AC-ALA-ALA-OH
• CAS NO: 19245-87-5
• Molecular Formula: C₈H₁₄N₂O₄
• Molecular Weight: 202.21
• Mol File: 19245-87-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 543.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.204±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.44±0.10(Predicted)
• CAS DataBase Reference: AC-ALA-ALA-OH(CAS DataBase Reference)
• NIST Chemistry Reference: AC-ALA-ALA-OH(19245-87-5)
• EPA Substance Registry System: AC-ALA-ALA-OH(19245-87-5)

Safety Data

• Hazardous Substances Data: 19245-87-5(Hazardous Substances Data)

Usage

General Description

AC-ALA-ALA-OH is a chemical compound that falls into the category of peptides. It is a short peptide consisting of three amino acids, Alanine (ALA), with an acetyl group (AC) attached to the N-terminus and a hydroxyl group (OH) attached to the C-terminus. AC-ALA-ALA-OH has been studied for its potential therapeutic applications in various fields, including drug delivery, wound healing, and as a potential anticancer agent. Its unique structure and properties make it a promising candidate for further research and development in the field of biomedicine and pharmaceuticals.

Upstream product

• 30802-26-7 N-acetyl-L-alanyl-L-alanine methyl ester 
• 60654-47-9 Ac-L-AlaN₂H₃ 
• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 108-24-7 acetic anhydride 
• 1948-31-8 di-L-alanine 
• 41036-19-5 L-alanyl-alanine methylester hydrochloride 
• 2483-51-4 N-[(benzyloxy)carbonyl]-L-alanyl-L-alanine methyl ester 

Downstream Products

• 90302-98-0 Ac-Ala₂-Phe-PheCH₂Cl 
• 90302-97-9 Ac-Ala₂-Leu-PheCH₂Cl 
• 90302-99-1 Ac-Ala₂-Pro-PheCH₂Cl 
• 90302-96-8 Ac-Ala₃-PheCH₂Cl 
• 38320-48-8 Ac-Ala₂-AlaCH₂Cl 
• 30802-29-0 Ac-Ala-Ala-Ala-Ala-OMe 

Relevant articles and documents

Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M2R Selectivity

Muscarinic acetylcholine receptors (MRs), comprising five subtypes (M1R-M5R) in humans, exhibit a high degree of structural similarity. Therefore, subtype-selective MR agonists and antagonists are lacking. We present an approach to highly M2R-selective MR antagonists based on the conjugation of di- or tripeptides to M2R-preferring dibenzodiazepinone-type MR antagonists. M2R selectivity was dependent on the peptide sequence and on the type of linker. The introduction of basic amino acids resulted in improved M2R selectivity (e.g., UR-AP148 (48): pKi (hM2R) of 8.97, ratio of Ki M1R/M2R/M3R/M4R/M5R of 49:1:6500:60:400) compared to reported pyridobenzo- and dibenzodiazepinone-type MR ligands. A supposed dualsteric binding mode of the DIBA-peptide conjugates, such as 48, at MRs was supported by molecular dynamics simulations.

The dimethylsulfoxonium methylide as unique reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-α-amino acid and N-Fmoc-peptide esters

The dimethylsulfoxonium methylide is described as a unique and useful reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-α-amino acid and N-Fmoc-peptide esters. The new methodology was applied successfully both to solution- and solid-phase peptide synthesis. The adopted methodology was extended successfully also to peptides containing amino acids bearing acid-sensitive protecting group in side chains. Furthermore no measurable epimerization was observed in the deprotection reaction of N-Fmoc-dipeptide methyl esters with dimethylsulfoxonium methylide.

Thermitase - A Thermostable Serine Protease. I. Synthesis of Alanine Peptide Esters as Substrates of the Enzyme

The synthesis of N-acetylated and N-succinylated peptide esters of alanine is described.The peptides are built up from the Z-protected peptides by liquid phase fragment condensation and by acylation of the deprotected peptide esters.The kinetic parameters Km and kcat of some compounds are presented.