Mal-amido-PEG8-TFP ester is a PEG (polyethylene glycol) linker that contains a maleimide and TFP (trifluorophenyl) ester end group. This unique structure allows for specific reactivity with thiols and primary amine groups, while also enhancing the water solubility of compounds in aqueous media. The maleimide group is particularly reactive with thiols in a pH range of 6.5 to 7.5, while the TFP ester is less prone to hydrolysis compared to NHS ester. The hydrophilic PEG chains, with their varying lengths, contribute to the improved water solubility of the compound, with longer PEG chains providing better solubility than shorter ones.
1924596-31-5
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Basic information
- Product Name: Mal-amido-PEG8-TFP ester
- Synonyms: Mal-amido-PEG8-TFP ester;Mal-NH-PEG8-TFP
- CAS NO:1924596-31-5
- Molecular Formula: C32H44F4N2O13
- Molecular Weight: 740.6909728
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1924596-31-5.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Mal-amido-PEG8-TFP ester(CAS DataBase Reference)
- NIST Chemistry Reference: Mal-amido-PEG8-TFP ester(1924596-31-5)
- EPA Substance Registry System: Mal-amido-PEG8-TFP ester(1924596-31-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1924596-31-5(Hazardous Substances Data)
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1924596-31-5 Usage
Uses
Used in Bioconjugation:Mal-amido-PEG8-TFP ester is used as a bioconjugation agent for the selective attachment of proteins, peptides, or other biomolecules to form stable conjugates. The maleimide group reacts with thiols, while the TFP ester reacts with primary amines, allowing for precise and efficient bioconjugation.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Mal-amido-PEG8-TFP ester is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The hydrophilic PEG chains enhance the water solubility of drugs, while the reactive end groups allow for the attachment of drug molecules to form stable conjugates.
Used in Diagnostics:
Mal-amido-PEG8-TFP ester is utilized as a component in the development of diagnostic tools, such as imaging agents and biosensors. The reactive end groups enable the attachment of diagnostic molecules to form stable conjugates, while the PEG chains improve the solubility and stability of the diagnostic agents.
Used in Material Science:
In the field of material science, Mal-amido-PEG8-TFP ester is used as a building block for the development of novel materials with enhanced properties. The reactive end groups allow for the attachment of various functional groups, while the PEG chains contribute to the improved solubility and stability of the resulting materials.
Used in Cosmetics:
In the cosmetics industry, Mal-amido-PEG8-TFP ester is used as an ingredient in skincare and hair care products to improve their efficacy and safety. The hydrophilic PEG chains enhance the water solubility of the product, while the reactive end groups allow for the attachment of beneficial active ingredients, such as antioxidants and moisturizing agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1924596-31-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,9,2,4,5,9 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.Calculate Digit Verification of CAS Registry Number 1924596-31:
(9*1)+(8*9)+(7*2)+(6*4)+(5*5)+(4*9)+(3*6)+(2*3)+(1*1)=205
205 % 10 = 5
So 1924596-31-5 is a valid CAS Registry Number.
1924596-31-5Upstream product
1924596-31-5Downstream Products
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Mal-amido-PEG8-TFP ester
