192513-05-6Relevant academic research and scientific papers
Synthesis and antibiofilm evaluation of 3-hydroxy-2,3-dihydroquinazolin-4(1H)-one derivatives against opportunistic pathogen Acinetobacter baumannii
Yang, Guo,Cheng, Cheng,Xu, Guo-Bo,Tang, Lei,Chua, Kim-Lee,Yang, Yuan-Yong
, (2020/07/07)
The emergence of multidrug resistant microorganisms has triggered the impending need for new aitimicrobial strategies. The antivirulence strategy with the benefite of alleviating the drug resistance becomes the focus of research. In this study, 22 quorum sensing inhibitors were synthesized by mimicking the structure of autoinducer and acinetobactin and up to 34% biofilm inhibition was observed with 5u. The biofilm inhibition effect was further demonstrated with extracellular polysaccharides inhibition and synergism with Gentamycin sulphate.
Reaction of o-aminobenzohydroxamic acid with aldehydes
Luk'yanov,Gordeev
, p. 110 - 112 (2007/10/03)
The reaction of o-aminobenzohydroxamic acid with aliphatic, aromatic, or heterocyclic aldehydes leads to the formation of derivatives of 3-hydroxy-1,2-dihydroquinazolin-4-one.
