19255-35-7 Usage
Uses
Used in Chemical Analysis:
1-(2,4-dinitrophenyl)-1-methylhydrazine is used as a reagent for the detection of aldehydes and ketones in organic compounds. It serves a crucial role in chemical analysis by forming derivatives with these compounds, which can then be identified and quantified through high-performance liquid chromatography (HPLC). This application is vital in various fields, including pharmaceuticals, environmental science, and materials research, where the accurate detection and quantification of aldehydes and ketones are essential for understanding the composition and properties of organic compounds.
Used in Research and Development:
In the realm of research and development, 1-(2,4-dinitrophenyl)-1-methylhydrazine is employed as a valuable tool for studying the chemical properties and reactivity of aldehydes and ketones. By forming derivatives with these compounds, researchers can gain insights into their structure, stability, and potential applications in various industries. This knowledge can be instrumental in the development of new materials, pharmaceuticals, and other products that rely on the unique properties of aldehydes and ketones.
Used in Quality Control and Compliance:
1-(2,4-dinitrophenyl)-1-methylhydrazine is also utilized in quality control processes to ensure the safety and efficacy of products containing aldehydes and ketones. By accurately detecting and quantifying these compounds, manufacturers can verify that their products meet industry standards and regulatory requirements. This application is particularly relevant in the pharmaceutical and cosmetics industries, where the presence of aldehydes and ketones can impact product performance and consumer safety.
Used in Environmental Monitoring:
In the field of environmental monitoring, 1-(2,4-dinitrophenyl)-1-methylhydrazine is employed to detect and quantify aldehydes and ketones in air, water, and soil samples. This information is crucial for assessing the environmental impact of various industrial processes and for developing strategies to mitigate the release of these compounds into the environment. By using DNPH as a reagent, researchers and environmental professionals can better understand the distribution and fate of aldehydes and ketones in the environment, ultimately contributing to the development of more sustainable practices and policies.
Check Digit Verification of cas no
The CAS Registry Mumber 19255-35-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,2,5 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 19255-35:
(7*1)+(6*9)+(5*2)+(4*5)+(3*5)+(2*3)+(1*5)=117
117 % 10 = 7
So 19255-35-7 is a valid CAS Registry Number.
19255-35-7Relevant academic research and scientific papers
1-Methyl-1-(2,4-dinitrophenyl)hydrazine as a New Reagent for the HPLC Determination of Aldehydes
Bueldt, Andrea,Karst, Uwe
, p. 3617 - 3622 (2007/10/03)
The synthesis and first application of an N-alkylated hydrazine reagent for the HPLC determination of aldehydes and ketones is described. 1-Methyl-1-(2,4-dinitrophenyl)hydrazine (MDNPH) reacts with aldehydes to give the corresponding hydrazones in the presence of an acid as catalyst. In contrast to other hydrazine reagents, MDNPH is oxidized by both ozone and nitrogen dioxide quantitatively to N-methyl-2,4-dinitroaniline (MDNA), which can be separated from the hydrazones of the lower aldehydes by means of HPLC. Unexpected elution orders are observed for the 1-methyl-1-(2,4-dinitrophenyl)hydrazones compared to those of 2,4-dinitrophenylhydrazones. Dual-wavelength detection is employed as a means for identification of different groups of the hydrazones and MDNA.
Competing Acyl Transfer and Intramolecular O --> N Acyl Group Migration from an Isolable O-Acylisourea
Hegarty, Anthony F.,McCormack, Margaret T.,Brady, Kieran,Ferguson, George,Roberts, Paul J.
, p. 867 - 875 (2007/10/02)
The O-acylisourea (16a), which is a model for the proposed intermediate in carbodi-imide condensations, and is formed on reaction of the chloride (15) with benzoate ion, was shown using X-ray crystallography to have the Z-configuration.Crystals are monoclinic, space group P21/c with four molecules in a cell of dimensions a = 15.732(3), b = 16.246(5), c = 7.628(1) Angstroem, β = 108.94(1) deg.The structure was solved by direct methods and refined by full-matrix least-squares calculations to an R value of 0.044 for 1 281 observed reflexions.The benzoyl group is trans to the lone pair of the imine nitrogen and the C=N bond length is 1.286(6) Angstroem.The isourea undergoes uncatalysed (at 25 degC in 1:4 dioxan-water, μ = 1.0) O --> N acyl transfer to give the N-acylamide (17) at pH > 7; the slow step is a Z --> E isomerization.At lower pH (3-6), Z --> E isomerization of the isourea (and thus O --> N acyl transfer) is acid catalysed, but at pH a of (16a), intramolecular acyl transfer is inhibited by protonation of the substrate.Competing intermolacular reaction of (16a) with the solvent occurs at all pH.In acid, reaction is between the protonated (16a) and water and in base between the free isourea (16a) and hydroxide ion.The O-acylisourea also undergoes rapid intermolecular acyl transfer to a variety of amines, although reaction between the free amine and protonated isourea was too slow to be observed.The implications of these results for the design of conditions to optimise inter- (rather than intra-) molecular reactions in carbodi-imide-mediated condensations is discussed.
