192564-25-3

Upstream product

• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 146557-84-8 3-Benzyloxymethyl-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 192564-24-2 3-Benzyloxymethyl-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-(3-oxo-butyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 192564-29-7 C₆₃H₈₁N₇O₁₀Si₂ 
• 192564-27-5 3-Benzyloxymethyl-1-{(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-[3-oxo-4-(triphenyl-λ⁵-phosphanylidene)-butyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: Synthesis of thymidine dinucleotide analogs with triazole-modified backbones

Novel backbone-modified dinucleotide analogs of types V and VI have been synthesized, where the natural phosphodiester linkage of a T-T dinucleotide has been replaced by a triazole heterocycle. The key step of the synthesis is the regioselective, thermal cycloaddition of a 2-oxoalkylidene triphenylphosphorane with an azide derivative to generate the triazole ring.