192570-60-8

Basic information

• Product Name: 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-6-nitro-quinazoline-2,4(3H)-dione
• CAS NO: 192570-60-8
• Molecular Weight: 625.635
• Mol File: 192570-60-8.mol

Chemical Properties

• CAS DataBase Reference: 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-6-nitro-quinazoline-2,4(3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-6-nitro-quinazoline-2,4(3H)-dione(192570-60-8)
• EPA Substance Registry System: 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-6-nitro-quinazoline-2,4(3H)-dione(192570-60-8)

Safety Data

• Hazardous Substances Data: 192570-60-8(Hazardous Substances Data)

Upstream product

• 192570-40-4 1-(3,5-di-O-p-toluoyl-2-deoxy-α,β-D-erythro-pentofuranosyl)-6-nitro-quinazoline-2,4(3H)-dione 
• 32618-85-2 6-Nitro-1H-quinazoline-2,4-dione 
• 3601-89-6 Hoffer's chlorosugar 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 

Relevant articles and documents

Tripler stability of oligodeoxynucleotides containing substituted quinazoline-2,4-(1H,3H)-dione

Triple helical structures can be observed between double-stranded nucleic acids and a third strand through the formation of Hoogsteen hydrogen bond. We report here the use of quinazoline-2,4-dione derivatives as substitutes for thymine in TA*T triplets. The synthesis and the characterization of monochloro derivatives of quinazoline-2,4-dione as well as 5-fluoro and 6-nitro substituted quinazoline rings are described. The ability of the various modified bases to promote the formation of triplexes was reached by thermal denaturation studies.