192573-56-1Relevant academic research and scientific papers
Elemental chalcogen (Se, S) in PEG-400 to the synthesis of seleno- And thioflavones from 2-chlorophenyl ethynyl ketone and nucleophilic species of chalcogen
Barcellos, Angelita M.,Barcellos, Thiago,Bartz, Ricardo H.,Jacob, Raquel G.,Nobre, Patrick C.,Peglow, Thiago J.,Perin, Gelson,Silva, Márcio S.
, p. 1541 - 1551 (2021/07/06)
An alternative green method was developed for the synthesis of thio- and selenoflavones by the ring closure of 2-chlorophenyl ethynyl ketone with NaHY (Y = S, Se). These nucleophilic chalcogen species were generated in situ using NaBH4 to reduc
Synthesis of N-alkyl-substituted 4-quinolones via tandem alkenyl and aryl C-N bond formation
Shao, Jun,Huang, Xiaomei,Hong, Xiaohu,Liu, Bingxin,Xu, Bin
, p. 1798 - 1808 (2012/08/08)
N-Alkyl-substituted 4-quinolones are present as the key structural motif in many marketed drugs. An efficient one-step tandem amination approach was developed to afford N-alkyl-substituted 4-quinolones in high yields from easily accessible o-chloroaryl acetylenic ketones and functionalized alkyl amines. The approach complements and extends our previous work. Compared with other reported methods, the current method provides a very simple and convenient route. Georg Thieme Verlag Stuttgart · New York.
