192573-57-2Relevant academic research and scientific papers
Synthesis of N-alkyl-substituted 4-quinolones via tandem alkenyl and aryl C-N bond formation
Shao, Jun,Huang, Xiaomei,Hong, Xiaohu,Liu, Bingxin,Xu, Bin
, p. 1798 - 1808 (2012/08/08)
N-Alkyl-substituted 4-quinolones are present as the key structural motif in many marketed drugs. An efficient one-step tandem amination approach was developed to afford N-alkyl-substituted 4-quinolones in high yields from easily accessible o-chloroaryl acetylenic ketones and functionalized alkyl amines. The approach complements and extends our previous work. Compared with other reported methods, the current method provides a very simple and convenient route. Georg Thieme Verlag Stuttgart · New York.
