1926-72-3

Upstream product

• 552-85-2 (+/-)-p-Hydroxy-norephedrin 
• 552-85-2 p-hydroxynorepherdine 
• 635304-44-8 (1R, 2S)-1-[4-(benzyloxy)phenyl]-2-[((1R)-phenylethyl)amino]-1-propanol 
• 25070-02-4 (1RS,2RS)-2-dibenzylamino-1-(4-benzyloxy-phenyl)-propan-1-ol 
• 100-46-9 benzylamine 
• 103-49-1 dibenzylamine 
• 104-88-1 4-chlorobenzaldehyde 
• 635304-65-3 (2S)-1-(4-hydroxyphenyl)-2-[((1R)-phenylethyl)amino]-1-propanone 
• 635304-39-1 (2S)-1-[4-(benzyloxy)phenyl]-2-[((1R)-phenylethyl)amino]-1-propanone methanesulfonate 
• 635304-43-7 (2R)-1-[4-(benzyloxy)phenyl]-2-[((1R)-phenylethyl)amino]-1-propanone hydrobromide 

Downstream Products

• 395-29-9 (-)-Isoxsuprin 
• 395-29-9 (+)-Isoxsuprin 
• 1027916-20-6 (4-{2-[(1S,2R)-2-Hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenylamino)-acetic acid ethyl ester 
• 227467-79-0 ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate 
• 227467-81-4 ethyl N-[2-chloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-N-methylaminoacetate 
• 227467-86-9 ethyl N-[2-bromo-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl) methylethyl]amino]ethyl]phenyl]aminoacetate 
• 227467-78-9 ethyl N-[2-chloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate 
• 1028271-87-5 (3-Chloro-4-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenylamino)-acetic acid ethyl ester 
• 227467-88-1 ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2-iodophenyl]aminoacetate 
• 247073-85-4 2-(3-Chloro-4-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenylamino)-2-methyl-propionic acid ethyl ester 
• 227467-74-5 ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate 
• 227467-87-0 ethyl N-[2,6-dibromo-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate 
• 227467-82-5 ethyl N-[2,3-dichloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate 
• 227467-83-6 ethyl N-[2,5-dichloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate 

Relevant academic research and scientific papers

Method for synthesizing ritodrine hydrochloride

The invention discloses a method for synthesizing ritodrine hydrochloride. The method comprises that p-chlorobenzaldehyde and pyruvic acid as substrates undergo a catalytic reaction, the product is purified to form (R)-1-(4-chlorophenyl)-1-hydroxypropane-2-one, the (R)-1-(4-chlorophenyl)-1-hydroxypropane-2-one and ammonium formate as substrates undergo a catalytic reaction, the product is purifiedto form (1R, 2S)-2-amino-1-(4-chlorophenyl)-1-propanol, the (1R, 2S)-2-amino-1-(4-chlorophenyl)-1-propanol and LiOH. H2O undergo a reaction to produce 4-((1R, 2S)-2-amino-1-hydroxypropyl)phenol and 4-((1R, 2S)-2-amino-1-hydroxypropyl)phenol and 4-(2-chloroethanol)phenol undergo a reaction to produce ritodrine hydrochloride. The method realizes a low cost, utilizes mild reaction conditions and issuitable for industrial production.

A NOVEL METHOD FOR SYNTHESIS OF OPTICALLY PURE BETA-AMINO ALCOHOLS

A method for the preparation of β-amino alcohol of formula (III) in which R1 is Ph, (substituted) Ph, R2 is C1-8 alkyl or C4-6 cyclo alkyl, R3 = R4R5CHNH2 where, R4 = H, C1-8 alkyl, C4-6 cyclo alkyl, or - COOR6 (R6=C1-C8 alkyl); R5 = (subst) aryl], the method including subjecting an α-hydroxy ketone of formula (I) in which R1 and R2 are as defined above is reacted with a chiral amine of formula R3NH2 where R3 = R4R5CH- where, R4 = H, C1-8 alkyl, C4-6 cycloalkyl, or - COOR6 (R6=C1-8 alkyl), R5 = (subst) aryl] to produce a compound of formula (II) in which R1, R2 and R3 are as defined above, followed by reduction to form the compound of formula (III).

PHENOL DERIVATIVES AND METHOD OF USE THEREOF

The present invention provides novel phenol derivatives represented by the formula: wherein the carbon atom marked with (S) represents a carbon atom in S configuration; Z represents the group represented by the formula: or the formula: wherein the carbon

PROCESS FOR PRODUCING OPTICALLY ACTIVE s-AMINO ALCOHOL

A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active α-substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active α-substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active β-substituted amino alcohol. The optically active β-substituted amino alcohol is subjected to hydrogenolysis to produce an optically active β-amino alcohol or a salt thereof.

Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4- hydroxyphenyl)-2-methylpyrido[3,4-b]pyrazin-7-yl]carbamate

Metabolism studies with ethyl [5-amino-1,2-dihydro-2-methyl-3- phenylpyrido[3,4-b]pyrazin-7-yl]carbamate (1) in mice were reported previously to give a hydroxylated metabolite, which was methylated to give a methoxy derivative. The metabolite and its deri