19260-55-0

Usage

Uses

Used in Oncology:
1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-, methyl ester is used as an antineoplastic agent for the treatment of various types of cancer, such as breast, bladder, and lung cancer, as well as leukemia and lymphoma. It inhibits the growth of cancer cells and disrupts their DNA replication processes, making it an effective treatment option for these conditions.
Used in Antimicrobial Applications:
Although primarily used for its antineoplastic properties, 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-, methyl ester also possesses antibiotic properties, which can be utilized in the treatment of certain bacterial infections. However, its primary use remains in oncology due to its significant impact on cancer treatment.

Upstream product

• 80173-04-2 methyl(9-RS,10-SR)-9-ethyl-6,9-dihydroxy-4-methoxy-5,12-dioxo-5,7,8,9,10,12-hexahydronaphthacene-10-carboxylate 
• 80173-04-2 c-2-Ethyl-1,2,3,4,6,11-hexahydro-t-2,5-dihydroxy-7-methoxy-6,11-dioxo-r-1-naphthacencarbonsaeure-methylester 
• 95456-15-8 3-(5,5-ethylenedioxyheptanoyl)-1,5-dimethoxy-4-methoxymethoxynaphthalene 
• 95455-82-6 methyl (6a-SR,9-RS,10-RS,10a-RS)-9-ethyl-5,9,12-trihydroxy-4-methoxy-6-oxo-6,6a,7,8,9,10,10a,11-octahydronaphthacene 
• 95455-97-3 methyl 4-(4'-hydroxy-5'-methoxy-1'-oxo-3'-(5''-oxoheptanoyl)-1',2'-dihydronaphth-2'-yl)-2-butenoate 
• 74188-46-8 4,5-Dihydroxy-9,10-dioxo-3-(3-oxopentyl)anthracene-2-acetic Acid, Methyl Ester 
• 135106-36-4 4-Hydroxy-5,8-dihydro-5,8-dioxo-3-(3-oxopentyl)-naphthaleneactic Acid, Methyl Ester 
• 97453-40-2 [9-(tert-Butyl-dimethyl-silanyloxy)-10-hydroxy-5-methoxy-4-oxo-3-(3-oxo-pentyl)-1,2,3,4-tetrahydro-anthracen-2-yl]-acetic acid methyl ester 
• 89101-88-2 methyl (6a-SR,9-RS,10-RS,10a-RS)-9-ethyl-12-t-butyldimethylsilyloxy-5,9-dihydroxy-4-methoxy-6-oxo-6,6a,7,8,9,10,10a,11-octahydronaphthacene-10-carboxylate 
• 89101-85-9 methyl 4-(1'-t-butyldimethylsilyloxy-4'-hydroxy-5'-methoxy-3'-(5''-oxoheptanoyl)-naphth-2'-yl)-2-butenoate 
• 89101-83-7 3-(5,5-ethylenedioxy-2-heptenoyl)-1,5-dimethoxy-4-methoxymethoxynaphthalene 
• 95456-16-9 1,5-dimethoxy-3-(5-oxoheptanoyl)-4-naphthol 
• 89101-84-8 5-methoxy-3-(5-oxoheptanoyl)-1,4-naphthoquinone 
• 95456-09-0 3-acetyl-1,5-dimethoxy-4-methoxymethoxynaphthalene 

Downstream Products

• 16234-96-1 t-2-Ethyl-1,2,3,4,6,11-hexahydro-c-2,t-4,5,7-tetrahydroxy-6,11-dioxo-r-1-naphthacencarbonsaeure-methylester 
• 78821-97-3 (+/-)-aklavinone 
• 16234-96-1 aklavinone 
• 16234-96-1 D-aklavinone 
• 16234-96-1 (+/-)-Aklavinon-I 

Relevant academic research and scientific papers

SYNTHESES OF (+/-)-AKLAVINONES. APPLICATION OF THE STEREOCONTROLLED "ZIPPER" BICYCLO-CYCLIZATION REACTION

Efficient syntheses of (+/-)-aklavinones; (+/-)-aklavinone (1), (+/-)-auramycinone (2), and (+/-)-13-methylaklavinone (3), are described.A key process of the tetracyclic ring construction in these syntheses is a stereocontrolled "zipper" bicyclo-cyclizati

An Efficient Total Synthesis of (+/-)-Aklavinone

An 11-step total synthesis of (+/-)-aklavinone from 1,3-cyclohexadione is reported.The key steps include a Diels-Alder condensation of 3 and 4 and the stereoselective aldol condensation of 21 to 22.The overall yield is ca. 13percent.