192642-82-3

Upstream product

• 192642-97-0 (E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide 
• 31181-64-3 5-bromo-2-methyl-pyridine-N-oxide 
• 31181-74-5 (5-bromopyridin-2-yl)methyl acetate 
• 88139-91-7 (5-bromopyridin-2-yl)methanol 
• 31181-90-5 5-bromo-pyridine-2-carbaldehyde 

Downstream Products

• 1024742-01-5 6-(p-tolylthio)[1,2,3]triazolo[1,5-a]pyridine 

Relevant academic research and scientific papers

PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY

The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

Copper-catalyzed aerobic carboxygenation and N-arylation of [1,2,3]triazolo[1,5-a]pyridines towards pyridinium triazolinone ylides

Copper-catalyzed aerobic oxyarylation of [1,2,3]triazolo[1,5-a]pyridines is developed. Notably molecular oxygen was utilized as one of the reagents and the transformation resulted in the formation of novel pyridinium triazolinone ylides. A basic mechanism for the one-pot process is proposed and further functionalization of the ylidic products were also presented.

ETHYNYL COMPOUNDS USEFUL FOR TREATMENT OF CNS DISORDERS

The present invention relates to ethynyl compounds of formula wherein X, Y, Z, and R4 are as defined herein or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) and they are therefore useful for the treatment of diseases related to this receptor.

Triazolopyridines. 18.1 nucleophilic substitution reactions on triazolopyridines; a new route to 2,2'-Bipyridines

The synthesis of some 5-, 6-, and 7-halogenotriazolopyridines is described and their reactions with nucleophiles. The formation or 7,7'-bitriazolopyridines provides a new synthesis of 2,2'-bipyridines.