192653-10-4

Upstream product

• 50-89-5 thymidine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 3587-60-8 Benzyloxymethyl chloride 
• 289681-49-8 1-[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(1,1-dimethylethyl)diphenylsilyl]oxy}tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione 
• 192653-08-0 3-Benzyloxymethyl-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 192653-09-1 3-N-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)thymidine 

Downstream Products

• 146557-84-8 3-Benzyloxymethyl-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Conception and Synthesis of Oxabicyclic Nucleoside Phosphonates as Internucleotidic Phosphate Surrogates in Antisense Oligonucleotide Constructs

The stereocontrolled synthesis of a novel oxabicyclic nucleoside phosphonate comprising a perhydrofuropyran core unit was achieved. It was incorporated in an oligonucleotide sequence as a 5′-3′ phosphonate-phosphate insert, and the stability properties of the resulting duplex were measured. The oxabicyclic nucleoside framework was designed so as to restrict rotation around angles ?, ?, and ? of a natural nucleoside.

Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: The effect of triazole- and imidazole-modified backbones on DNA/RNA duplex stability

Thymidine dinucleotide analogs with imidazole-derived backbones (III and IV) were synthesized. These modified dimeric building blocks were incorporated into oligodeoxyribonucleotides. The hybridization affinity of the modified oligonucleotides for RNA complements was determined and compared to the corresponding olefinic modifications I and II.