192697-89-5Relevant academic research and scientific papers
Cocaine catalytic antibodies: The primary importance of linker effects
Matsushita, Masayuki,Hoffman, Timothy Z.,Ashley, Jon A.,Zhou, Bin,Wirsching, Peter,Janda, Kim D.
, p. 87 - 90 (2007/10/03)
Current treatments for cocaine addiction are not effective. The development of a catalytic monoclonal antibody (mAb) provides a strategy for not only binding, but also degrading cocaine, which offers a broad-based therapy. Hapten design is the central element for programming antibody catalysis. The characteristics of the linker used in classic transition-state analogue phosphonate haptens were shown to be important for obtaining mAbs that hydrolyze the benzoate ester of cocaine.
