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PD 166866 is a potent ATP competitive pyrido[2,3-d]pyrimidine tyrosine kinase inhibitor, specifically targeting fibroblast growth factor receptor 1 (FGFR1). It exhibits high selectivity for FGFR1 over other kinases such as PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4. PD 166866 effectively inhibits FGFR1 autophosphorylation and the phosphorylation of MAPK, reducing FGF-stimulated growth and displaying inhibitory effects on non-small cell lung cancer (NSCLC) cell lines.
Used in Pharmaceutical Industry:
PD 166866 is used as a therapeutic agent for targeting fibroblast growth factor receptor 1 (FGFR1) in the treatment of various diseases, including cancer.
Used in Cancer Research:
PD 166866 is used as a research tool for studying the role of FGFR1 in cancer progression and as a potential therapeutic agent for inhibiting the growth of non-small cell lung cancer (NSCLC) cell lines in a dose-dependent manner.
Used in Angiogenesis Inhibition:
PD 166866 is used as an inhibitor of angiogenesis, reducing microvessel outgrowth from human placental arteries in vitro, which can be beneficial in the development of anti-angiogenic therapies.
Used in Cell Migration Studies:
PD 166866 is used to study the effects of FGFR1 inhibition on cell migration, as it has been shown to reduce the migration of VL-8 cells at a concentration of 10 μM.
Chemical Properties:
PD 166866 is an off-white solid, which is an important characteristic for its formulation and stability in pharmaceutical applications.

192705-79-6

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192705-79-6 Usage

Biochem/physiol Actions

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.

Check Digit Verification of cas no

The CAS Registry Mumber 192705-79-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,7,0 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 192705-79:
(8*1)+(7*9)+(6*2)+(5*7)+(4*0)+(3*5)+(2*7)+(1*9)=156
156 % 10 = 6
So 192705-79-6 is a valid CAS Registry Number.

192705-79-6 Well-known Company Product Price

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  • Sigma

  • (PZ0114)  PD-166866  ≥98% (HPLC)

  • 192705-79-6

  • PZ0114-5MG

  • 1,048.32CNY

  • Detail

  • Sigma

  • (PZ0114)  PD-166866  ≥98% (HPLC)

  • 192705-79-6

  • PZ0114-25MG

  • 4,201.47CNY

  • Detail

192705-79-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

1.2 Other means of identification

Product number -
Other names 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:192705-79-6 SDS

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