192710-91-1

Upstream product

• 3840-30-0 5-(chloromethyl)-1,2,3-trimethoxybenzene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 108683-61-0 triphenyl(3,4,5-trimethoxybenzyl)phosphonium chloride 
• 192711-11-8 2-((tert-butyldimethylsilyl)oxy)-4-methoxybenzaldehyde 

Relevant academic research and scientific papers

Synthesis of biologically active polyphenolic glycosides (combretastatin and resveratrol series)

(E)-3-(β-D-Glucopyranosyloxy)-4',5-dihydroxystilbene (resveratrol 3-β-D-glucoside, piceid), (Z)-2',3'-dihydroxy-3,4,4',5-tetramethoxystilbene (combretastatin A-1), (Z)-3'-hydroxy-3,4,4', 5-tetramethoxystilbene (combretastatin A-4), (Z)-2'-hydroxy-3,4,4',5-tetramethoxystilbene (combretastatin iso-A-4), α,β-dihydro-2',3'-dihydroxy-3,4,4',5-tetramethoxystilbene (combretastatin B-1), the corresponding glucosides, and related compounds have been synthesized via Wittig reactions followed by,glucosylation under phase-transfer catalysis. Most of the compounds synthesized have been tested with respect to biological activity (cytostatic, cytotoxic, antimitotic, neurotoxic, antiplatelet aggregation activity).