192710-92-2Relevant academic research and scientific papers
(E)-1-(2-Hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene.
Zhang, Jianxing,Chen, Shou Feng,Klausmeyer, Kevin K,Kane, Robert R
, p. o381-382 (2003)
In the crystal structure of the title compound, C(18)H(20)O(5), all geometric parameters fall within experimental error of the expected values. Analysis of the molecular-packing plots reveals an infinite one-dimensional linear array running parallel to the c axis, formed by an O-H...O intermolecular hydrogen-bonding interaction. The stilbene framework and most of the substituents are approximately coplanar.
Trans-O-hydroxy-diphenyl ethylene derivatives and its preparation method and application
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Paragraph 0048, (2016/12/01)
The invention discloses a trans-o-hydroxy stilbene derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: in the presence of a rhodium catalyst and acetate, reacting an o-hydroxy styrene compound with arylboronic acid in a solvent, and after the reaction is completed, treating, thereby obtaining the trans-o-hydroxy stilbene derivative. The preparation method is mild in reaction conditions, procedures are simple and can be rapidly performed, and the yield is relatively high. The cell experiment shows that compared with resveratrol, a product prepared from the trans-o-hydroxy stilbene derivative is generally better in anti-tumor activity.
Synthesis and antiproliferative evaluation of 2-hydroxylated (E)-stilbenes
Zhang, Yan,Shen, Mingyun,Cui, Sunliang,Hou, Tingjun
supporting information, p. 5470 - 5472 (2015/02/19)
A simple synthesis of 2-hydroxylated (E)-stilbenes was accomplished in good yields via oxidative coupling of 2-hydroxystyrenes and arylboronic acids, with Rh(III)-catalyst and Cu(OAc)2 as oxidant. The antiproliferative evaluation of all the synthesized compounds were assessed on four different human cancer cell lines (Colo-205, MDA-468, HT29, and MGC80-3), and the results showed that several compounds exhibit strong antiproliferative activities (up to IC50 = 35 nM for MGC80-3).
Synthesis of biologically active polyphenolic glycosides (combretastatin and resveratrol series)
Orsini, Fulvia,Pelizzoni, Francesca,Bellini, Barbara,Miglierini, Giuliana
, p. 95 - 109 (2007/10/03)
(E)-3-(β-D-Glucopyranosyloxy)-4',5-dihydroxystilbene (resveratrol 3-β-D-glucoside, piceid), (Z)-2',3'-dihydroxy-3,4,4',5-tetramethoxystilbene (combretastatin A-1), (Z)-3'-hydroxy-3,4,4', 5-tetramethoxystilbene (combretastatin A-4), (Z)-2'-hydroxy-3,4,4',5-tetramethoxystilbene (combretastatin iso-A-4), α,β-dihydro-2',3'-dihydroxy-3,4,4',5-tetramethoxystilbene (combretastatin B-1), the corresponding glucosides, and related compounds have been synthesized via Wittig reactions followed by,glucosylation under phase-transfer catalysis. Most of the compounds synthesized have been tested with respect to biological activity (cytostatic, cytotoxic, antimitotic, neurotoxic, antiplatelet aggregation activity).
