192725-84-1Relevant academic research and scientific papers
Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea - Synthesis and structure-activity relationships
Sham, Hing L.,Betebenner, David A.,Rosenbrook, William,Herrin, Thomas,Saldivar, Ayda,Vasavanonda, Sudthida,Plattner, Jacob J.,Norbeck, Daniel W.
, p. 2643 - 2645 (2007/10/03)
The HIV protease inhibitor ABT-378 (lopinavir) has a six-member cyclic urea in the P-2 position. A series of analogues in which the six-member cyclic urea is replaced by various heterocycles was synthesized and the structure-activity relationships explored.
Retroviral protease inhibiting compounds
-
Page 56, (2010/01/31)
A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.
