192725-86-3

Usage

Chemical Properties

Pale Yellow Oil

Uses

Intermediate in the preparation of Lopinavir metabolites.

Upstream product

• 13211-31-9 tert-butyl L-valinate 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 221553-72-6 (S)-N-{(1S,3S,4S)-1-Benzyl-4-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-hydroxy-5-phenyl-pentyl}-2-(4-hydroxy-2-oxo-tetrahydro-pyrimidin-1-yl)-3-methyl-butyramide 
• 192725-39-6 4-Oxo-ABT-378 
• 192725-87-4 N-(2-carboxamido)ethyl-L-valine t-butyl ester 

Relevant academic research and scientific papers

Retroviral protease inhibiting compounds

A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.

Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)

The HIV protease inhibitor ABT-378 (Lopinavir) is metabolized rapidly and extensively by CYP-3A4 catalyzed oxidation. Three of the major metabolites identified were synthesized and their antiviral (HIV) activities determined.

RETROVIRAL PROTEASE INHIBITING COMPOUNDS

A compound of the formula: STR1 is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.